Lancet:鲁索利替尼治疗白癜风II期临床获得成功

2020-07-11 网络 网络

鲁索利替尼乳膏可使白癜风皮损部位在52周内有明显的色素沉着,且耐受性良好

白癜风是一种慢性自身免疫性疾病,导致患者皮肤色素脱失,生活质量下降。目前有效的白癜风色素沉着疗法,近日研究人员考察了鲁索利替尼乳膏对白癜风患者的治疗潜力。
 
研及人员在美国26家医院和医疗中心招募成年白癜风患者进行了一项多中心、随机、双盲、二期研究。0.5%或以上面部体表面积(BSA)和3%或以上非面部BSA脱色患者接受鲁索利替尼乳膏(含量1.5%每日两次,含量1.5%每日一次,含量0.5%每日一次,含量0.15%每日一次)或安慰剂,每天2次,每次治疗占总BSA的20%或以下,持续24周。除含量0.15%每日一次组的患者外,在第24周时面部白癜风面积评分指数(F-VASI)与基线相比没有出现25%或更高改善的患者,被重新分组接受更高剂量的鲁索利替尼乳膏(0.5%每日一次,1.5%每日一次,1.5%每日两次)直到第52周。研究的主要终点是在意向治疗人群中,在第24周F-VASI(F-VASI50)较基线改善50%或更高的患者比例。
 
157名患者(平均年龄,48.3岁,73名[46%]男性和84名[54%]女性)参与研究,其中32例(20%)为对照组,31例(20%)为0.15%每日一次组,31例(20%)为0.5%每日一次组,30例(19%)为1.5%每日一次组,33例(21%)为1.5%每日两次组。使用1.5%的鲁索利替尼乳膏每日2次(15 /33)和1.5%每日一次(15 / 30)组患者,在第24周达到F-VASI50的患者比例明显多于对照组(1/32)。4例患者出现严重不良事件(1.5%每日两次组中有1例出现硬膜下血肿;1.5%每日一次组中有1例癫痫发作;0.5%每日一次组中有1例冠状动脉闭塞;0.5%每日一次组中有1例出现食管贲门失弛缓症),但均与研究治疗无关。鲁索利替尼组最常见的不良事件为瘙痒(1.5%每日两次组33例中有1例;1.5%每日一次组中30例中有3例;0.5%每日一次组中31例中有3例;0.15%每日一次组中31例中有6例),其中对照组32例中有3例出现用药部位瘙痒。在125例接受鲁索利替尼乳膏的患者中有13例(10%)和接受对照组乳膏32例患者中的1例(3%)出现痤疮,被认为是与治疗相关的不良事件。 所有与治疗相关的不良事件均为轻度或中度。
 
研究发现,鲁索利替尼乳膏可使白癜风皮损部位在52周内有明显的色素沉着,且耐受性良好。
 
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    2021-12-26 屋顶瞄爱赏月

    学习了

    0

  3. 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    2021-12-18 屋顶瞄爱赏月

    每日一学

    0

  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033878, encodeId=184a10338e8e4, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 11 12:44:35 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2021-04-20 ms6000000837768418

    学到了

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033878, encodeId=184a10338e8e4, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 11 12:44:35 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
  6. 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Dec 04 05:44:35 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890110, encodeId=400089011067, content=<a href='/topic/show?id=74a11029119e' target=_blank style='color:#2F92EE;'>#鲁索替尼#</a>治疗白癜风,效果如此之好,实际上未来脱发,白发,都可能是JAK抑制剂治疗的天下了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102911, encryptionId=74a11029119e, topicName=鲁索替尼)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Oct 04 21:47:54 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813725, encodeId=04e5813e25a7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 08:02:14 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524834, encodeId=77aa1524834f7, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Mon Jul 13 00:44:35 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033878, encodeId=184a10338e8e4, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 11 12:44:35 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-12-04 howi
  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c4a5474237, createdName=ms6000000837768418, createdTime=Tue Apr 20 16:37:08 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653052, encodeId=51a716530522b, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Thu Oct 15 17:44:35 CST 2020, time=2020-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830734, encodeId=4fe61830e34ce, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Dec 04 05:44:35 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890110, encodeId=400089011067, content=<a href='/topic/show?id=74a11029119e' target=_blank style='color:#2F92EE;'>#鲁索替尼#</a>治疗白癜风,效果如此之好,实际上未来脱发,白发,都可能是JAK抑制剂治疗的天下了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102911, encryptionId=74a11029119e, topicName=鲁索替尼)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Oct 04 21:47:54 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813725, encodeId=04e5813e25a7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 08:02:14 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524834, encodeId=77aa1524834f7, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Mon Jul 13 00:44:35 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033878, encodeId=184a10338e8e4, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 11 12:44:35 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-10-04 lovetcm

    #鲁索替尼#治疗白癜风,效果如此之好,实际上未来脱发,白发,都可能是JAK抑制剂治疗的天下了

    0

  8. 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Dec 04 05:44:35 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890110, encodeId=400089011067, content=<a href='/topic/show?id=74a11029119e' target=_blank style='color:#2F92EE;'>#鲁索替尼#</a>治疗白癜风,效果如此之好,实际上未来脱发,白发,都可能是JAK抑制剂治疗的天下了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102911, encryptionId=74a11029119e, topicName=鲁索替尼)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Oct 04 21:47:54 CST 2020, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033878, encodeId=184a10338e8e4, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 11 12:44:35 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-08-27 14818eb4m67暂无昵称

    学习了

    0

  9. 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  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033878, encodeId=184a10338e8e4, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jul 11 12:44:35 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-07-11 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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Northwestern大学将针对白癜风的DNA药物专利转让给Temprian Therapeutics

Temprian Therapeutics宣布获得Northwestern大学转让的专利,该专利是靶向热休克蛋白HSP70i的DNA药物,旨在逆转白癜风引起的皮肤颜色损失。

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白癜风是一种慢性自身免疫性疾病,全球范围内大概1%的人口罹患此病。很少有大规模的研究探讨白癜风患者的不良妊娠结局。

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