CHEST:OSA综合征严重影响创伤后应激障碍患者的症状和生活质量

2016-02-12 MedSci MedSci原创

研究人员试图确定OSA综合征(OSAS)对于创伤后应激障碍(PTSD)患者的症状和生活质量(QOL)的影响。此外,研究人员还评估了在该人群中气道正压(PAP)的治疗的依从性和响应。这是在学术军事医疗中心的睡眠障碍中心进行的病例对照观察性队列研究。200例连续PTSD患者接受睡眠评估。研究人员对患有PTSD并有和没有OSAS的患者与50名连续年龄匹配的患友OSAS但无PTSD患者和50名年龄匹配的正

研究人员试图确定OSA综合征(OSAS)对于创伤后应激障碍(PTSD)患者的症状和生活质量(QOL)的影响。此外,研究人员还评估了在该人群中气道正压(PAP)的治疗的依从性和响应。

这是在学术军事医疗中心的睡眠障碍中心进行的病例对照观察性队列研究。200例连续PTSD患者接受睡眠评估。研究人员对患有PTSD并有和没有OSAS的患者与50名连续年龄匹配的患友OSAS但无PTSD患者和50名年龄匹配的正常对照患者进行了比较。研究人员获得了多导睡眠监测数据,睡眠相关的症状和QoL结果,并客观使用了PAP。

在PTSD患者中,超过一半(56.6%)的患者接受OSAS的诊断。与其他各组相比,PTSD和OSAS患者有较低的QoL,并且更嗜睡。PTSD患者对于PAP治疗表现出显著较低的依从性和响应。单独患有OSAS的82%患者解决了嗜睡的问题,PAP-依从性62.5%的患者解决了嗜睡的问题,PTSD和OSAS非依从性患者的21.4%解决了嗜睡问题(P<0.001)。同样,OSAS患者72%治疗后睡眠功能结果问卷≥17.9,而只有56.3%的PAP依从性PTSD和OSA患者达到该分数,非依从性患者只有26.2%(P<0.03)达到。

PTSD患者,共患OSAS与较差的症状,QoL,以及对PAP的依从性和响应有关。鉴于对结果的负面影响,PTSD患者应仔细考虑OSAS的可能性。需要密切随访,以优化在这个高危人群PAP依从性和有效性。

原始出处:

Christopher J. Lettieri,Scott G. Williams,Jacob F. Collen,OSA Syndrome and Posttraumatic Stress Disorder,CHEST,2016.2.11

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    2017-01-27 Smile2680
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    2016-02-14 hb2008ye
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    2016-02-14 bioon3
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