Cardiovasc Diabetol ：利拉鲁肽与生活方式改变对肥胖糖尿病前期患者或减肥后的2型糖尿病患者Sst2和Galectin-3的影响

2022-03-16 从医路漫漫 MedSci原创

心肌纤维化的特征是细胞外基质(ECM)蛋白在心脏间质中积聚，并与许多心脏病理生理状况有关。

背景：心肌纤维化的特征是细胞外基质(ECM)蛋白在心脏间质中积聚，并与许多心脏病理生理状况有关。实验和临床证据都表明心脏纤维化改变可能是可逆的。可溶性肿瘤抑制因子-2(Sst2)和半乳糖凝集素-3(Galectin-3)是纤维化和炎症及其相互作用的两个生物标志物，被认为反映了心肌纤维化。多项队列研究支持使用这些分子的血浆水平来跟踪导致心力衰竭的疾病状态，并获得重要的预后信息。此外，这些ECM重塑的标记物也可能有助于识别最有可能从各种治疗中受益的患者亚群。

可溶性Sst2是白细胞介素1(IL-1)受体家族成员，分泌到循环中，作为IL-33的“诱饵”受体，抑制心脏保护性IL-33/ST2信号转导。它最初被归类为心肌细胞应激的指标，但它主要产生于心外组织对炎症和纤维化刺激的反应。在缺血性病因的慢性心力衰竭(HF)患者中，Sst2水平与血流介导的扩张呈负相关，反映了体内的内皮功能。更高的Sst2水平也被报道为冠心病合并和不合并T2 DM患者的主要心血管不良事件和全因死亡的独立预测因子，以及慢性心力衰竭患者的心血管死亡和与HF相关的住院治疗的独立预测因子，与射血分数无关。Gal-3是一种具有糖识别域的β-半乳糖苷结合凝集素，是另一种在细胞外基质重塑和炎症中起重要作用的分子，也与血管生成、炎症或纤维化和心肌衰竭有关。

利拉鲁肽是胰高糖素样肽-1(GLP-1)的类似物，用于治疗2型糖尿病。一项双盲试验显示，在心血管风险较高的糖尿病患者中，服用利拉鲁肽的复合终点发生率(包括心血管原因死亡率、非致命性心肌梗死或非致命性中风)低于安慰剂。体外和体内证据表明，心脏纤维化的改善可能是这一发现之外的可能机制之一。沿着这些思路，一项随机、安慰剂对照研究报告了利拉鲁肽对非酒精性脂肪性肝炎的组织学改善。然而，尽管炎症和纤维化及其相互作用是T2 DM的重要特征，但关于Sst2，特别是糖尿病的数据很少。

方法：40例糖尿病前期[空腹血糖受损或糖耐量受损或两者兼有]或新诊断为T2 DM的肥胖者(体重指数≥为30)，随机接受利拉鲁肽或生活方式咨询，直至达到相当的体重下降(初始体重的7%)。13名受试者作为健康对照，检测基线Sst2和Gal-3水平

结果：对照组和肥胖组的基线Sst2水平相近(p=0.79)，而Gal-3水平显著高于对照组(p<0.001)。利拉鲁肽治疗降低了血浆Sst2水平(−为9%，β=−14.9，标准差为6.9，p=0.037)，而Gal3水平没有变化。干预后，由于生活方式组增加了19%(p=0.29)，利拉鲁组降低了25%(p=0.033)，血清超敏肌钙蛋白I降低了(组间差异p=0.083)。较低的基线Gal-3水平预示着利拉鲁肽治疗后β细胞功能有较好的改善。

图1基线血浆Sst2和Gal-3水平。随机选取的对照组和患者的血清Sst2(A)和Gal-3(B)基线水平比较

图2血清hs-TnI与血浆Sst2(A)和Gal-3(B)的基线相关性

图3 OGTT期间干预对血浆ST2和Gal-3水平的影响。减肥前(A，C)和(B，D)后生活方式和利拉鲁肽组OGTT中Sst2和Gal-3的水平

结论：利拉鲁肽诱导的Sst2和hs-TnI的减少表明，在肥胖的糖尿病前期或早期T2 DM患者中，该药物可能对(心脏)纤维化有积极作用，而利拉鲁肽开始治疗前的血浆Gal-3水平可能预测该药物对β细胞功能改善的反应。

原文出处：Simeone P, Tripaldi R, Michelsen A,et al.Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss.Cardiovasc Diabetol 2022 Mar 11;21(1)

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#利拉鲁肽#与#生活方式#改变对#肥胖##糖尿病#前期患者或#减肥#后的#2型糖尿病#患者#sST2#和#Galectin-3#的影响，Gal-3是重要的#炎症##标志物#，值得深入研究

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encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475238, encodeId=355014e52385c, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245515, encodeId=9b181245515ce, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 16 23:06:38 CST 2022, time=2022-03-16, status=1, ipAttribution=)]
2022-06-16 ms4657536712156177

#ST2#

48 0
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channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=69141, encryptionId=405269141c9, topicName=生活方式), TopicDto(id=81891, encryptionId=3ad9818917c, topicName=肥胖), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病), TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥), TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病), TopicDto(id=16720, encryptionId=9ede16e20f8, topicName=sST2), TopicDto(id=7814, encryptionId=a0f3e814af, topicName=Galectin-3), TopicDto(id=67001, encryptionId=53c66e0011b, topicName=炎症), TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 03:28:50 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=2068102, encodeId=bb23206810277, content=<a href='/topic/show?id=3e9816e266d' target=_blank style='color:#2F92EE;'>#ST2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16726, encryptionId=3e9816e266d, topicName=ST2)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Thu Jun 16 17:06:38 CST 2022, time=2022-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640090, encodeId=e7d11640090e7, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Nov 18 05:06:38 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774449, encodeId=dda71e74449c8, content=<a href='/topic/show?id=a0f3e814af' target=_blank style='color:#2F92EE;'>#Galectin-3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7814, encryptionId=a0f3e814af, topicName=Galectin-3)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68c038536731, createdName=liuquanmn, createdTime=Thu Feb 16 19:06:38 CST 2023, time=2023-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249528, encodeId=726512495284e, content=<a href='/topic/show?id=401e3230391' target=_blank style='color:#2F92EE;'>#利拉鲁肽#</a>与<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Sat Sep 17 06:37:26 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939328, encodeId=dc271939328b0, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 15 16:06:38 CST 2022, time=2022-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761876, encodeId=09311e6187683, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Jul 26 03:06:38 CST 2022, time=2022-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383766, encodeId=c30a1383e66e6, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475238, encodeId=355014e52385c, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245515, encodeId=9b181245515ce, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 16 23:06:38 CST 2022, time=2022-03-16, status=1, ipAttribution=)]
2022-11-18 ms9608593228839890

#DIA#

38 0
[GetPortalCommentsPageByObjectIdResponse(id=2118377, encodeId=9db621183e750, content=<a href='/topic/show?id=401e3230391' target=_blank style='color:#2F92EE;'>#利拉鲁肽#</a>与<a href='/topic/show?id=405269141c9' target=_blank style='color:#2F92EE;'>#生活方式#</a>改变对<a href='/topic/show?id=3ad9818917c' target=_blank style='color:#2F92EE;'>#肥胖#</a><a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>前期患者或<a href='/topic/show?id=023031264fd' target=_blank style='color:#2F92EE;'>#减肥#</a>后的<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>患者<a href='/topic/show?id=9ede16e20f8' target=_blank style='color:#2F92EE;'>#sST2#</a>和<a href='/topic/show?id=a0f3e814af' target=_blank style='color:#2F92EE;'>#Galectin-3#</a>的影响，Gal-3是重要的<a href='/topic/show?id=53c66e0011b' target=_blank style='color:#2F92EE;'>#炎症#</a><a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>，值得深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=69141, encryptionId=405269141c9, topicName=生活方式), TopicDto(id=81891, encryptionId=3ad9818917c, topicName=肥胖), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病), TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥), TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病), TopicDto(id=16720, encryptionId=9ede16e20f8, topicName=sST2), TopicDto(id=7814, encryptionId=a0f3e814af, topicName=Galectin-3), TopicDto(id=67001, encryptionId=53c66e0011b, topicName=炎症), TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 03:28:50 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=2068102, encodeId=bb23206810277, content=<a href='/topic/show?id=3e9816e266d' target=_blank style='color:#2F92EE;'>#ST2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16726, encryptionId=3e9816e266d, topicName=ST2)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kbRUeosenzlejlNGWXdWjSYhBKL1QYGQwfehJOkMXHiavh5wl7pKeju5Kcxdvr50ic6FWML3x6NMCxhG1bOaVjyA/132, createdBy=20872500216, createdName=ms4657536712156177, createdTime=Thu Jun 16 17:06:38 CST 2022, time=2022-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640090, encodeId=e7d11640090e7, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Nov 18 05:06:38 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774449, encodeId=dda71e74449c8, content=<a href='/topic/show?id=a0f3e814af' target=_blank style='color:#2F92EE;'>#Galectin-3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7814, encryptionId=a0f3e814af, topicName=Galectin-3)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68c038536731, createdName=liuquanmn, createdTime=Thu Feb 16 19:06:38 CST 2023, time=2023-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249528, encodeId=726512495284e, content=<a href='/topic/show?id=401e3230391' target=_blank style='color:#2F92EE;'>#利拉鲁肽#</a>与<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Sat Sep 17 06:37:26 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939328, encodeId=dc271939328b0, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jul 15 16:06:38 CST 2022, time=2022-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761876, encodeId=09311e6187683, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Jul 26 03:06:38 CST 2022, time=2022-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383766, encodeId=c30a1383e66e6, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475238, encodeId=355014e52385c, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245515, encodeId=9b181245515ce, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 16 23:06:38 CST 2022, time=2022-03-16, status=1, ipAttribution=)]
2023-02-16 liuquanmn

#Galectin-3#

61 0
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 16 23:06:38 CST 2022, time=2022-03-16, status=1, ipAttribution=)]
2022-09-17 小小医者

#利拉鲁肽#与#糖尿病#

68 0
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2022-07-15 quxin068

#ASC#

30 0
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encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475238, encodeId=355014e52385c, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245515, encodeId=9b181245515ce, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 16 23:06:38 CST 2022, time=2022-03-16, status=1, ipAttribution=)]
2022-07-26 ms5439512287675881

#BET#

28 0
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 16 23:06:38 CST 2022, time=2022-03-16, status=1, ipAttribution=)]
2022-03-18 aids213

#2型糖尿病患者#

28 0
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 16 23:06:38 CST 2022, time=2022-03-16, status=1, ipAttribution=)]
2022-03-18 xue8604

#糖尿病患者#

29 0
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encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475238, encodeId=355014e52385c, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 18 11:06:38 CST 2022, time=2022-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1245515, encodeId=9b181245515ce, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 16 23:06:38 CST 2022, time=2022-03-16, status=1, ipAttribution=)]
2022-03-16 CHANGE

什么时候有懒人用的减肥神药？

25 0

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Cardiovasc Diabetol ：利拉鲁肽与生活方式改变对肥胖糖尿病前期患者或减肥后的2型糖尿病患者Sst2和Galectin-3的影响

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