Diabetes Care:2型糖尿病患者椎体骨折

2019-10-29 xing.T MedSci原创

由此可见,根据该研究的发现,应该系统地评估T2D患者VF的患病率。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估2型糖尿病(T2D)患者是否具有增加椎体骨折(VFs)的风险,并评估T2D和VF患者的非椎体骨折和死亡风险。

研究人员系统地检索了PubMed,以确定探究T2D与VF之间关系的研究。提供个人参与者数据(IPD)的队列也包括在内。来自已发表的汇总数据估计和随机效应荟萃分析中对IPD队列的汇总。研究人员使用多变量Cox回归模型对T2D和VF患者的非椎骨骨折和死亡风险进行分析。

在15项针对852705名男性和女性的研究中,T2D患者的患病风险较低(比值比[OR]为0.84 [95%CI为0.74–0.95]; I2=0.0%;P=0.54),但发生VF的风险增加(OR为1.35 [95%CI为1.27–1.44];I2=0.6%;P=0.43)。在IPD队列中(N=19,820),T2D和VF患者的非椎骨骨折的风险高于没有T2D或VF的患者(风险比[HR]为2.42 [95%CI为1.86-3.15])、VFs患者( HR为1.73 [95%CI为1.32–2.27])或T2D患者(HR为1.94 [95%CI为1.46–2.59])。与没有T2D和VF的患者(HR为2.11 [95%CI为1.72–2.59])或仅有VF的患者(HR为1.84 [95%CI为1.49–2.28])相比,同时患有T2D和VFs的患者死亡率增加(HR为1.23 [95%CI为0.99–1.52])。

由此可见,根据该研究的发现,应该系统地评估T2D患者VF的患病率。 

原始出处:

Fjorda Koromani,et al.Vertebral Fractures in Individuals With Type 2 Diabetes: More Than Skeletal Complications Alone.Diabetes Care.2019.https://doi.org/10.2337/dc19-0925

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    2019-10-31 dingxiaobo
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    2019-10-29 misszhang

    谢谢MedSci提供最新的资讯

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