J Periodontol:基台表面制备负载盐酸米诺环素的氧化石墨烯薄膜对种植体周围炎的作用

2020-06-27 MedSci原创 MedSci原创

由于种植体周围疾病,例如种植体周围炎,仍然会发生种植牙失败的情况。本研究旨在检测种植体基台表面上制备负载盐酸米诺环素(MH)的氧化石墨烯(GO)薄膜对比格犬的种植体周围炎的作用。

由于种植体周围疾病,例如种植体周围炎,仍然会发生种植牙失败的情况。本研究旨在检测种植体基台表面上制备负载盐酸米诺环素(MH)的氧化石墨烯(GO)薄膜对比格犬的种植体周围炎的作用。

使用丝线结扎建立比格犬种植体周围炎模型。检测改良的龈沟出血指数,种植体周围探诊深度,放射线,显微CT断层扫描分析和组织学评估,以评估基台表面负载MH的GO膜对种植体周围炎的治疗效果。

X线和micro-CT分析显示,Ti和MH / Ti组,尤其是Ti组,可检测到大量边缘性骨吸收。 GO / Ti组可见胡搜阿亮的骨吸收,而MH / GO / Ti组的骨吸收可忽略不计。组织学分析结果表明,Ti和MH / Ti组可检测到大量中性粒细胞。但是,在GO / Ti和MH / GO / Ti组骨细胞数量多,几乎没有观察到中性粒细胞。

因此,种植体基台表面有负载MH的GO膜可能会抑制种植体周围炎的进一步发展,并对比格犬的种植体周围炎有较好的治疗效果。

原文出处:

Wenhao Qian,Minocycline hydrochloride‐loaded graphene oxide films on implant abutments for peri‐implantitis treatment in beagle dogs. Journal of periodontology, 2020 June. Doi: 10.1002/JPER.19-0285

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    2021-03-21 feather89
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    2020-11-28 huangdf
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