Ann Rheum Dis:HLA I类和II类等位基因在强直性脊柱炎易感性中的作用

2018-10-26 xiangting MedSci原创

这些数据证实除HLA-B*27之外,其他HLA I类和II类等位基因也在AS易感性中起作用。

这篇文章旨在探讨3个欧洲、亚洲和非洲血统的患者队列中,HLA I类和II类等位基因与强直性脊柱炎(AS)的相关性。

将来自前瞻性强直性脊柱炎队列结局研究、北美脊柱炎协会和澳-英-美脊柱炎协会的1948名无血缘白人AS患者和67名非洲裔美国AS患者,以及990名白人对照和245名非洲裔美国对照的HLA-A、HLA-B、HLA-C、HLA-DRB1、HLA-DQB1和HLA-DPB1等位基因进行基因分型。将442名中国汉族AS患者和来自上海和甘肃的346名对照者的HLA-B等位基因进行基因分型。除了病例:对照分析之外,还对HLA-B*27阴性的AS患者单独进行分析,使用logistic回归和"相对易感效应"(RPE)分析以控制HLA-B*27对疾病易感性的主要影响。

尽管在白人中观察到HLA等位基因与AS存在大量关联,但在HLA-B*27阴性的AS患者中,HLA-A*29、B*38、B*49、B*52、DRB1*11和DPB1*03:01与AS呈正相关,HLA-B*07、HLA-B*57、HLA-DRB1*15:01、HLA-DQB1*02:01和HLA -DQB1*06:02与AS呈负相关。通过RPE分析观察到AS与HLA-B*14和B*40(B60)存在额外关联,这排除了HLA-B*27等位基因。HLA-B*40:01频率升高和HLA-B*07频率降低也可见于中国汉族和非洲裔美国AS患者。伴急性前葡萄膜炎的白人患者HLA-B*08频率降低。

该研究分析了3个种族中迄今为止数量最多的AS患者,这些数据证实除HLA-B*27之外,其他HLA I类和II类等位基因也在AS易感性中起作用。

始出处:
John D Reveille. HLA class I and II alleles in susceptibility to ankylosing spondylitis. Ann Rheum Dis. 19 October 2018.

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    2019-04-26 zywlvao
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    2018-10-28 marongnuan
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    2018-10-26 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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J Rheumatol:强直性脊柱炎假关节的影像学和病理学研究

AS相关性假关节更可能起源于机械创伤,而不是炎症。

Semin Arthritis Rheu:男性强直性脊柱炎患者TNF-α抑制剂治疗期间的影像学进展多于女性

男性和女性患者在TNF-α抑制剂治疗期间的临床改善相当。然而,2年后男性患者的影像学脊柱损伤更为明显。

脊柱关节炎与强直性脊柱炎的流行病学

脊柱关节炎(Spondyloarthritis,SpA)是指一类累及中轴和(或)外周关节的慢性炎症性疾病,具有明显的家族聚集倾向,SpA包括强直性脊柱炎(AnkylosingSpondylitis,AS)、反应性关节炎、银屑病关节炎等已有明确分类标准的疾病类型,但其最常见(>50%)的类型为未分化脊柱关节炎(UndifferentiatedSpondyloarthritis,uSpA),uSpA是

浅谈强直性脊柱炎的发病机制

强直性脊柱炎(Ankylosing Spondylitis, AS)是一种主要侵犯骶髂关节及脊柱中轴关节为主要病变的慢性进行性炎症性疾病。尤其以骶髂关节、脊柱及外周关节的骨化强直和外周附着点病理性成骨为特点,脊柱和关节骨化强直是AS患者致残的主要原因。目前,AS病因及发病机制尚不明确,大多数研究认为与遗传、感染、免疫、环境因素等有关。