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BMJ：高温与心梗风险一过性升高相关

2012-12-20 BMJ 医学论坛网 高晓方 编译

高温心梗风险
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  　　英国学者的一项研究表明，20°C以上环境高温与心肌梗死风险一过性升高具有相关性。论文于2012年12月13日在线发表于《英国医学杂志》（BMJ）。 　　此项病例交叉研究共纳入24,861例在最炎热月份（6～8月份）心肌梗死住院患者。主要转归指标为气温每升高1°C的心肌梗死比值比。相关数据来源于英国国家心肌缺血项目基础数据库（MINAP）。 　　结果显示，暴露于估计阈值温度（

高温
 

　　英国学者的一项研究表明，20°C以上环境高温与心肌梗死风险一过性升高具有相关性。论文于2012年12月13日在线发表于《英国医学杂志》（BMJ）。

　　此项病例交叉研究共纳入24,861例在最炎热月份（6～8月份）心肌梗死住院患者。主要转归指标为气温每升高1°C的心肌梗死比值比。相关数据来源于英国国家心肌缺血项目基础数据库（MINAP）。

　　结果显示，暴露于估计阈值温度（20°C）以上1～6小时后，炎热对心肌梗死具有显著影响。阈值温度以上每升高1°C，心肌梗死风险升高1.9%（P=0.009）。后期风险降低可在一定程度上抵消早期风险升高；炎热暴露3天后阈值温度以上每升高1°C的累积效应为0.2%。

与心梗相关的拓展阅读：


Heat and risk of myocardial infarction: hourly level case-crossover analysis of MINAP database

Objective 
To quantify the association between exposure to higher temperatures and the risk of myocardial infarction at an hourly temporal resolution.
Design 
Case-crossover study.
Setting 
England and Wales Myocardial Ischaemia National Audit Project (MINAP) database.
Participants 
24 861 hospital admissions for myocardial infarction occurring in 11 conurbations during the warmest months (June to August) of the years 2003-09.
Main outcome measure 
Odds ratio of myocardial infarction for a 1°C increase in temperature.
Results 
Strong evidence was found for an effect of heat acting 1-6 hours after exposure to temperatures above an estimated threshold of 20°C (95% confidence interval 16°C to 25°C). For each 1°C increase in temperature above this threshold, the risk of myocardial infarction increased by 1.9% (0.5% to 3.3%, P=0.009). Later reductions in risk seemed to offset early increases in risk: the cumulative effect of a 1°C rise in temperature above the threshold was 0.2% (2.1% to 2.5%) by the end of the third day after exposure.
Conclusions 
Higher ambient temperatures above a threshold of 20°C seem to be associated with a transiently increased risk of myocardial infarction 1-6 hours after exposure. Reductions in risk at longer lags are consistent with heat triggering myocardial infarctions early in highly vulnerable people who would otherwise have had a myocardial infarction some time later (“short term displacement”). Policies aimed at reducing the health effects of hot weather should include consideration of effects operating at sub-daily timescales.

    

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    2013-05-20 cy0324

    #心梗风险#

    0

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    2013-04-14 Luyuxie_9

    #一过性#

    0

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    2013-08-23 gaoxiaoe

    #BMJ#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2016065, encodeId=482c201606593, content=<a href='/topic/show?id=1f5a510e731' target=_blank style='color:#2F92EE;'>#心梗风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51077, encryptionId=1f5a510e731, topicName=心梗风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon May 20 17:32:00 CST 2013, time=2013-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007678, encodeId=cef7200e6787b, content=<a href='/topic/show?id=166319451a7' target=_blank style='color:#2F92EE;'>#一过性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19451, encryptionId=166319451a7, topicName=一过性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Sun Apr 14 07:32:00 CST 2013, time=2013-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847484, encodeId=8593184e484b2, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Fri Aug 23 02:32:00 CST 2013, time=2013-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506510, encodeId=965e1506510e4, content=<a href='/topic/show?id=89061024e70b' target=_blank style='color:#2F92EE;'>#高温#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102477, encryptionId=89061024e70b, topicName=高温)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90ad9763425, createdName=lqrandywkz, createdTime=Sat Dec 22 07:32:00 CST 2012, time=2012-12-22, status=1, ipAttribution=)]
    2012-12-22 lqrandywkz

    #高温#

    0