Am J Clin Nutr:少量或适量饮酒可降低2型糖尿病风险

2016-02-05 Seven L 译 MedSci原创

研究者检索了PubMed、Embase、Cochrane Library等数据库,纳入与“饮酒量和2型糖尿病风险”间相关研究,进行剂量反应荟萃分析。荟萃分析最终纳入了26项研究,涉及706716名参与者,其中275711名为男性,431005名为女性,有31621名2型糖尿病患者。数据显示,无论是所有队列,还是男性女性,饮酒量和2型糖尿病风险间存在非线性的关系(P-trend < 0.001

研究者检索了PubMed、Embase、Cochrane Library等数据库,纳入与“饮酒量和2型糖尿病风险”相关的研究,进行剂量反应荟萃分析。

荟萃分析最终纳入了26项研究,涉及706716名参与者,其中275711名为男性,431005名为女性,有31621名2型糖尿病患者。

数据显示,无论是所有队列,还是男性或女性中,饮酒量和2型糖尿病风险间存在非线性的关系(P-trend < 0.001, P-nonlinearity < 0.001)。与最小饮酒量相比,少量(RR: 0.83; 95% CI: 0.73, 0.95; P = 0.005) 和适中(RR: 0.74; 95% CI: 0.67, 0.82; P < 0.001) 的饮酒均可以降低2型糖尿病风险。但是大量饮酒对随后的2型糖尿病风险没有影响。适度饮酒与最小饮酒量相比,2型糖尿病的总RR率(RRR,男vs女)更高;少量饮酒的合并RRR(当前吸烟vs不吸烟)更低。

荟萃分析结果表明,并不是“喝酒就能降低2型糖尿病风险”,其中存在一个量的问题;少量和适中的饮酒可以降低2型糖尿病风险,但是大量饮酒就不能降低其风险。

原始出处:

Xiao-Hua Li, Fei-fei Yu, et al.Association between alcohol consumption and the risk of incident type 2 diabetes: a systematic review and dose-response meta-analysis.Am J Clin Nutr.First published February 3, 2016, doi: 10.3945/​ajcn.115.114389


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  2. [GetPortalCommentsPageByObjectIdResponse(id=1956274, encodeId=c66a19562e42b, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Tue May 03 17:11:00 CST 2016, time=2016-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63630, encodeId=9a04636302d, content=可能吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Feb 07 16:40:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63606, encodeId=32d1636062e, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Sun Feb 07 14:43:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63607, encodeId=4f4f6360e1d, content=非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Sun Feb 07 14:43:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490052, encodeId=ea031490052ad, content=<a href='/topic/show?id=254794e30b0' target=_blank style='color:#2F92EE;'>#适量饮酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94730, encryptionId=254794e30b0, topicName=适量饮酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sat Feb 06 16:11:00 CST 2016, time=2016-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63505, encodeId=7b1f635056e, content=酒,少喝为好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Feb 06 12:17:00 CST 2016, time=2016-02-06, status=1, ipAttribution=)]
    2016-02-07 忠诚向上

    可能吗

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1956274, encodeId=c66a19562e42b, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Tue May 03 17:11:00 CST 2016, time=2016-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63630, encodeId=9a04636302d, content=可能吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Feb 07 16:40:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63606, encodeId=32d1636062e, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Sun Feb 07 14:43:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63607, encodeId=4f4f6360e1d, content=非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Sun Feb 07 14:43:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490052, encodeId=ea031490052ad, content=<a href='/topic/show?id=254794e30b0' target=_blank style='color:#2F92EE;'>#适量饮酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94730, encryptionId=254794e30b0, topicName=适量饮酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sat Feb 06 16:11:00 CST 2016, time=2016-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63505, encodeId=7b1f635056e, content=酒,少喝为好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Feb 06 12:17:00 CST 2016, time=2016-02-06, status=1, ipAttribution=)]
    2016-02-07 1de48a27m96(暂无匿称)

    了解

    0

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    2016-02-07 1de48a27m96(暂无匿称)

    非常好

    0

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    2016-02-06 医者仁心5538

    酒,少喝为好。

    0

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【囧说】酒文化源远流长,其中的段子可不少!上面我们谈了喝酒的成分,这篇文章搜集了一下关于酒文化的段子。 喜酒的人士可以在酒桌上用一用,劝酒更有效!不喜酒的可以了解了解,拒酒更有法! 【1】 “你把我灌醉,又不跟我睡” 【2】 喝酒象喝汤,此人在工商。 喝酒象喝水,此人在建委。 人均喝一瓶,此人在财政。 喝酒不用劝,此人在法院。 举杯一口干,此人是公安。

Nature & Transl Psych:酒后失态原来也是基因在捣鬼

图片来源:medicalxpress.com 近日,一项刊登在国际杂志Translational Psychiatry上的研究报告中,来自赫尔辛基大学的科学家通过研究发现了一种遗传突变,该突变可是的携带者喝醉酒后出现特别冲动和鲁莽的行为,研究者指出,在芬兰超过10万人都携带这种突变。 许多芬兰人都知道有些人喝醉后会行为会变得过度奇怪且不稳定,文章中研究者推测这或许是某些生物因素所导致的;研

PNAS:喝酒脸红人群可能具有肝癌风险

导读线粒体乙醛脱氢酶2(Mitochondrial aldehyde dehydrogenase 2, ALDH2)可去除有毒醛类,包括乙醇代谢的中间产物乙醛。近40%的东亚人表达一个失活的ALDH2*2变异,其中在位置487(E487K),谷氨酸被赖氨酸取代,临床表现即为饮酒后脸红,同时此类型的人群可能具有胃肠道肿瘤的高风险。 线粒体乙醛脱氢酶2(Mitochondrial aldeh

揭开八大致命饮酒误区

谎言一、喝酒红脸不易醉 一些人认为喝了酒面红如关公是好事,代表血液循环好,能迅速分解酒精,不易醉。但专家指出,酒量和脸色没有太大关系,因人而异。事实上,导致很多人认为喝酒脸红的人不容易醉的原因其实是,红脸的人大家一般少劝酒,因此喝得少,加上酒后发困,睡上15-30分钟就又精神抖擞了,而白脸的则往往不知自己的底线,在高度兴奋中饮酒过量。 谎言二、浓茶咖啡可醒酒 事实上这是一种误解。酒

Eur Heart J:中年早期人群适度喝酒可降未来心衰风险

众所周知,酒精具有心脏毒性,如果过多摄入可导致心力衰竭(HF)。但无论是男性还是女性,其适度酒精摄入与心衰风险的关系尚未知。2015年1月20日在线发表于《欧洲心脏杂志》(Eur Heart J)杂志的一项研究回答了上述问题,研究者发现,中年早期人群每周酒精摄入达7杯(98 g酒精)与其将来心衰风险较小有相关性,女性与男性人群的这种相关性相似,但在女性中不十分确定。研究结果进一步表明,尽管过量