JCO：早期拉帕替尼联用曲妥单抗对HER2+乳腺癌效果更优

2015-07-14 MedSci MedSci原创

人类表皮生长因子受体2（HER2/neu）在肿瘤发生过程中起到了中心的作用。曲妥单抗是治疗HER2阳性转移性乳腺癌的一线用药，单独使用曲妥单抗可以大约三分之一患者产生响应。当曲妥单抗和化疗相结合，响应率则更高。临床前试验表明曲妥单抗和HER2直接酪氨酸激酶抑制剂拉帕替尼之间存在协同作用。研究人员召集了两组受试者，第一组没有优先使用曲妥单抗治疗HER2阳性转移性乳腺癌并且超过

人类表皮生长因子受体2（HER2/neu）在肿瘤发生过程中起到了中心的作用。曲妥单抗是治疗HER2阳性转移性乳腺癌的一线用药，单独使用曲妥单抗可以大约三分之一患者产生响应。当曲妥单抗和化疗相结合，响应率则更高。临床前试验表明曲妥单抗和HER2直接酪氨酸激酶抑制剂拉帕替尼之间存在协同作用。

研究人员召集了两组受试者，第一组没有优先使用曲妥单抗治疗HER2阳性转移性乳腺癌并且超过一年没有使用辅助曲妥单抗；第二组为使用包括曲妥单抗进行化疗和/或复发小于一年。研究人员检验了药物联用并探索使用18F-去氧葡萄糖正电子发射断层显像技术（[18F]FDG-PET）用于临床结果的估测。试验共采集了85例有效数据。两组确信的客观响应率分别为50.0%(95%CI，33.8%-66.2%)和40.0%（95%CI，25.7%-55.7%）。无进展中位存活时间分别为7.4和5.3个月。在第一周以及治疗后的第八周进行全身PET扫描。使用欧洲癌症研究和治疗组织的条件对超过五处靶标损伤进行评价。

此次研究表明，早期联用曲妥单抗和拉帕替尼对于HER2阳性转移性乳腺癌的治疗是有效的。第一周的FDG-PET扫描或许可以使得病人可以使用有针对性的处方。当然，此次研究仍存在一些局限性，比如在许多情况下，帕妥珠单抗-曲妥单抗-紫杉烷联用更优。

原始出处：

Nancy U. Lin, Hao Guo, Jeffrey T. Yap, Ingrid A. Mayer, Carla I. Falkson, Timothy J. Hobday, E. Claire Dees, Andrea L. Richardson, Rita Nanda, Mothaffar F. Rimawi, Nicole Ryabin, Julie S. Najita, William T. Barry, Carlos L. Arteaga, Antonio C. Wolff, Ian E. Krop, Eric P. Winer, and Annick D. Van den Abbeele.Phase II Study of Lapatinib in Combination With Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer: Clinical Outcomes and Predictive Value of Early [18F]Fluorodeoxyglucose Positron Emission Tomography Imaging (TBCRC 003). J Clin Oncol. 2015 Jul 13. pii: JCO.2014.60.0353 doi: 10.1200/JCO.2015.60.8620

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2021-02-19 dearluodi

学习了，谢谢学习了，谢谢

59 0
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2021-02-19 dearluodi

学习了，谢谢

53 0
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2021-02-19 dearluodi

学习了，谢谢

49 0
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2021-02-19 dearluodi

学习了，谢谢

59 0
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2021-02-19 dearluodi

学习了，谢谢

57 0
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2021-02-19 dearluodi

学习了，谢谢

22 0
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2021-02-19 dearluodi

学习了，谢谢

21 0
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2021-02-19 dearluodi

学习了，谢谢

25 0
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2015-08-02 lidong40

#JCO#

32 0
[GetPortalCommentsPageByObjectIdResponse(id=925594, encodeId=5e0492559426, content=学习了，谢谢学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:32:44 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925592, encodeId=ca4992559232, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:32:35 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925591, encodeId=86a89255911a, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:32:27 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925590, encodeId=5d1392559027, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:32:24 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925589, encodeId=b87c925589b7, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:32:16 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925577, encodeId=ca0f9255e714, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:29:30 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925576, encodeId=488e9255e610, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:29:26 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925575, encodeId=17729255e5e4, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Fri Feb 19 22:28:58 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1891199, encodeId=43921891199fc, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sun Aug 02 23:35:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38964, encodeId=85153896440, content=Ok, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3601615208, createdName=dearluodi, createdTime=Thu Oct 15 20:43:00 CST 2015, time=2015-10-15, status=1, ipAttribution=)]
2015-10-15 dearluodi

Ok

51 0

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