BMJ:周围细颗粒物污染与特定心血管疾病的住院人数之间的关联

2020-01-27 不详 MedSci原创

本项研究旨在评估中国人群因短期暴露于环境细颗粒物(空气动力学直径≤2.5μm; PM 2.5)污染而引起的特定心血管疾病的住院风险之间的关系。

背景及目的:
本项研究旨在评估中国人群因短期暴露于环境细颗粒物(空气动力学直径≤2.5μm; PM 2.5)污染而引起的特定心血管疾病的住院风险之间的关系。

方法:
本项研究为时间序列研究,研究人员收集了2014年1月1日至2017年12月31日中国184个城市的8834533因心血管原因住院的人群的临床数据。主要观察结局是主要诊断为缺血性心脏病,心力衰竭,心律失常,缺血性中风和出血性中风的每日住院情况,以评估PM 2.5与发病率之间的关系。

结果:
在研究期间,心血管疾病平均每天住院47例,缺血性心脏病平均26例,心衰1例,心律失常2例,缺血性中风为14,出血性中风为2例。在全国平均水平上,PM 2.5的增加量为10μg/m3心血管疾病的住院人数增加0.26%(95%置信区间0.17%至0.35%),缺血性心脏病0.31%(0.22%至0.40%),心力衰竭0.27%(0.04%至0.51),心律失常的0.29%(0.12%至0.46%)和缺血性卒中的0.29%(0.18%至0.40%)有关,PM 2.5为15-25、25-35、35-75和75μg/m3或更多与心血管疾病住院率的增加显着相关,分别为1.1%(0至2.2%),1.9%(0.6%)至3.2%),2.6%(从1.3%至3.9%)和3.8%(从2.1%至5.5%)。根据预测,达到中国2级(35μg/m3),中国1级(15μg/m3)和世界卫生组织(10μg/m3)的年度平均PM 2.5浓度监管限值将降低中国每年心血管疾病的入院人数。

结论:
本项研究数据表明,在中国,短期暴露于PM 2.5与除出血性中风以外的所有主要心血管疾病的住院人数增加有关。

原始出处:

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    2020-06-21 lisa449
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    2020-06-05 gaoxiaoe
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