AIDS 2014:抗癌药能激活休眠HIV病毒

2014-07-24 佚名 生物谷

抗癌药物能唤醒隐藏在病人体内的HIV病毒。研究人员认为,这个发现将为治愈艾滋病提供新方向。 据报道,关于抗癌药物罗米地辛(Romidepsin)的研究结果22日在墨尔本举行的世界艾滋病大会(International AIDS Conference)上公布。研究人员乐观地表示,治愈艾滋病的方法也许会在未来出现。 丹麦奥胡斯大学(Aarhus University)索佳德博士(Ole Schm

抗癌药物能唤醒隐藏在病人体内的HIV病毒。研究人员认为,这个发现将为治愈艾滋病提供新方向。

据报道,关于抗癌药物罗米地辛(Romidepsin)的研究结果22日在墨尔本举行的世界艾滋病大会(International AIDS Conference)上公布。研究人员乐观地表示,治愈艾滋病的方法也许会在未来出现。

丹麦奥胡斯大学(Aarhus University)索佳德博士(Ole Schmeltz Sogaard)是本次研究的主要负责人。HIV能以休眠方式隐藏在CD4细胞中。尽管药物能抑制病人体内的HIV水平,但仍然没有彻底消除HIV病毒的方法。研究人员向6名HIV病人提供抗癌药物,发现抗癌药物能分辨正在休眠的HIV病毒,并让其离开藏身之处。研究人员也发现,对于受到HIV病毒感染的细胞中,抗癌药物能把病毒复制水平提升至正常水平的2至4倍。因此,研究人员能追踪这些细胞。

“我们发现罗米地辛能激活休眠中的HIV病毒,而量的被激活病毒会流进血液。这显示出,我们在治愈艾滋病的路途上踏出了正确一步,但路依然漫长,障碍依然很多。”索佳德博士说。

加利福尼亚大学(University of California)研究人员迪克斯(Steve Deeks)表示,丹麦方面的发现具有重大意义。“至少在我看来,这是第一个能发现隐藏HIV病毒及让其离开藏身之处的明确证据。下一个研究步骤将是如何杀死这些病毒。”

HIV研究人员希望通过激活休眠细胞,并利用现有的治疗方法或试验中的疫苗来消除这些有害细胞。

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    2015-04-01 yese
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    2015-02-07 wjywjy
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    2014-07-26 sunylz
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    2014-07-26 cooco
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