J Gastroen Hepatol:嗜酸性粒细胞形态变化定量检测用于无创嗜酸性粒细胞性食管炎确诊

2017-07-02 zhangfan MedSci原创

嗜酸性粒细胞形态变化定量检测是无创的,可行的,简单以及可靠的嗜酸性粒细胞性食管炎确诊方法

嗜酸性粒细胞增多是嗜酸性粒细胞性食管炎(EOE)的主要疾病特征。近日研究人员评估了无创嗜酸性粒细胞活化检测在疾病诊断中的作用。

研究人员通过外周血嗜酸性粒细胞形态学评估嗜酸性粒细胞的激活状态在EoE患者和对照组之间的差异,同时对患者进行环氧合酶-2以及5-脂氧合酶免疫荧光显微镜评估以确定EOE患者血液中的嗜酸性粒细胞活化途径。

研究发现,EoE患者其血液中的嗜酸性粒细胞活化程度显著高于对照组。对照组正常状态的嗜酸性粒细胞比例最低为40%而 EoE 患者正常的嗜酸性粒细胞比例最高仅为32%。若正常嗜酸性粒细胞水平低于36%则确诊患者为EOE的敏感性为100%。检测发现EOE患者的嗜酸性粒细胞活化通过环氧合酶-2途径。

研究表明嗜酸性粒细胞形态变化定量检测是无创的,可行的,简单以及可靠的嗜酸性粒细胞性食管炎确诊方法。

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    2017-07-02 许安
  4. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150714/IMG55A4FADCE0F987688.jpg, createdBy=23af1632396, createdName=1dd8f26bm82(暂无匿称), createdTime=Tue Jul 04 06:46:50 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437214, encodeId=2bc7143e214ff, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jul 03 21:44:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324612, encodeId=1373132461293, content=<a 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topicId=null, topicList=[TopicDto(id=40241, encryptionId=48524024105, topicName=嗜酸性粒细胞性食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a38986122, createdName=tidiq, createdTime=Mon Jul 03 21:44:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217792, encodeId=1e4321e792ba, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Jul 02 11:18:29 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-04 1dd8f26bm82(暂无匿称)

    好资源

    0

  5. 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topicId=null, topicList=[TopicDto(id=40241, encryptionId=48524024105, topicName=嗜酸性粒细胞性食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a38986122, createdName=tidiq, createdTime=Mon Jul 03 21:44:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217792, encodeId=1e4321e792ba, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Jul 02 11:18:29 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-03 zhouqu_8
  6. 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  7. 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    2017-07-03 gwc384
  8. 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  9. 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  10. 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    2017-07-02 明月清辉

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