Psychooncology:你知道担忧癌症复发与自身健康存在怎样的相关性吗?

2017-07-01 肿瘤资讯 肿瘤资讯

癌症患者和幸存者都会时常担忧癌症复发。那么,是什么驱动患者产生这种担忧呢?患者对于癌症复发的担忧是否会影响其自身健康呢?近期,来自英国圣安德鲁斯大学医学院Gerald Humphris团队进行的荟萃分析发现,手术后再行化疗,与患者对癌症复发的担忧之间存在较弱的相关性。

癌症患者和幸存者都会时常担忧癌症复发。那么,是什么驱动患者产生这种担忧呢?患者对于癌症复发的担忧是否会影响其自身健康呢?近期,来自英国圣安德鲁斯大学医学院Gerald Humphris团队进行的荟萃分析发现,手术后再行化疗,与患者对癌症复发的担忧之间存在较弱的相关性。

癌症患者和幸存者都会时常担忧癌症复发。过去10余年来,越来越多的研究者开展了这方面的研究,评估患者担忧对自身健康状态的影响。研究结果显示,那些对癌症复发非常担忧的患者,其自诉的生活质量更差,且更容易出现抑郁,需要更多的健康照护。他们倾向于联想癌症会悄无声息的复发,因此,身体上任意的阵痛或不适都会让他们认为癌症复发。

尽管过去的研究报道,不同患者对癌症复发的担忧程度存在很大差异,但对于复发的担忧确实是非常严重的问题。根据既往的研究结果估计,近50%的癌症患者对癌症的复发呈中等或极度担忧,其中10%的患者为极度担忧。此外,超过60%的乳腺癌患者自诉希望和自己的专科医生诉说他们的担忧。

近期,英国圣安德鲁斯大学医学院发表的最新报道再次确认:接受化疗的患者相比于单纯手术的患者,更易出现对癌症复发的担忧。研究者通过系统性检索既往文献,纳入了29项研究,共30176例患者。荟萃分析结果显示,接受化疗的患者与癌症复发担忧之间存在相关性,有统计学意义,但相关系数较小,提示相关性较弱(r=0.093,95%CI:0.062-0.123;P<0.001)。

这一结果与该团队既往关于放疗与癌症复发担忧相关性的研究结果相似。2016年,他们团队发表一项关于“放疗与癌症复发的担忧相关性”的荟萃分析显示,接受放疗的患者与癌症复发担忧之间存在相关性,有统计学意义,但相关系数较小,提示相关性较弱(r=0.053,95%CI:0.021-0.085;P=0.001)。

这一研究的主要研究者Humphris博士介绍道:这一结果并不让人吃惊,患者接受更广泛的治疗,通常就会表现得更担忧或恐惧。但是,近年来也提出一种解释:既然已接受了多种手段的联合抗肿瘤治疗,那么患者应该更有可能相信癌症已经被“治愈”了。如果患者能够逐渐接受后面这一解释,那么这一相关性应该会减弱。的确,我们也看到化疗与癌症复发担忧的相关性随时间呈现减弱趋势。这也意味着,未来这一相关性可能不复存在。当然,这一相关性减弱也可能是其他原因共同作用的结果。如临床医生与患者解释为什么进行化疗的方式与既往不同,目前的患者谈话,可能更多的侧重于让患者相信,手术后更多的治疗对降低复发风险非常重要。

然而,我们在评估放疗与患者复发担忧的关系上,没有发现这一相关性有减弱的趋势。这可能是因为,患者会更多的认为放疗是诱发新肿瘤的危险因素,而非为了“治愈” 肿瘤;这与患者对化疗的认知存在差异。当然,这只是目前的猜测,需要进一步的验证。

对不同类型的肿瘤患者进行亚组分析,研究者还发现,乳腺癌患者中,接化疗与癌症复发担忧的相关性最强。这可能是医生对乳腺癌患者的解释,更多的强调化疗的目的是为了降低复发风险。在这种情况下,患者可能更多的是关注医生谈到的复发,而没有在意化疗的作用。如果该项研究中这一亚组分析的结果,能在后续的研究中得以证实,那么乳腺癌患者化疗的与癌症复发担忧的相关性是值得进一步研究的。

目前,Humphris博士团队正在致力于如何帮助患者建立对癌症诊断和治疗的认知。一旦患者萌发对复发的恐惧,这一恐惧将持续存在,很难减弱。因此,从一开始就尽力尝试防止患者产生这一恐惧。Humphris团队和其他同道们正一起合作,致力于帮助癌症治疗团队共同照护患者,度过治疗期。其初步的研究显示,这一方法将减缓患者短期的担忧。

关于这些担忧如何影响患者,该团队还需进一步研究。小编希望这一结果早日公布,从而更好的帮助患者克服担忧和恐惧。

原始出处:

Yang Y, Cameron J, Humphris G. The relationship between cancer patient's fear of recurrence and radiotherapy: a systematic review and meta-analysis. Psychooncology. 2017 Jun;26(6):738-746. doi: 10.1002/pon.4224. 

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    2021-02-08 陈SY

    这些天天说“学习的是不是机器人,?

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  4. 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  5. 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href='/topic/show?id=7eb6e134273' target=_blank style='color:#2F92EE;'>#癌症复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71342, encryptionId=7eb6e134273, topicName=癌症复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fad3959854, createdName=lq0302, createdTime=Mon Jul 03 13:46:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218025, encodeId=14c721802575, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jul 03 07:33:59 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217809, encodeId=42dd21e809df, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Jul 02 12:56:05 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2018-02-15 minlingfeng
  6. 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href='/topic/show?id=7eb6e134273' target=_blank style='color:#2F92EE;'>#癌症复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71342, encryptionId=7eb6e134273, topicName=癌症复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fad3959854, createdName=lq0302, createdTime=Mon Jul 03 13:46:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218025, encodeId=14c721802575, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jul 03 07:33:59 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217809, encodeId=42dd21e809df, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Jul 02 12:56:05 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-08 wxl882001

    学习一下

    0

  7. 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href='/topic/show?id=7eb6e134273' target=_blank style='color:#2F92EE;'>#癌症复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71342, encryptionId=7eb6e134273, topicName=癌症复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fad3959854, createdName=lq0302, createdTime=Mon Jul 03 13:46:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218025, encodeId=14c721802575, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jul 03 07:33:59 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217809, encodeId=42dd21e809df, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Jul 02 12:56:05 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-05 日月生辉

    主观因素的研究,很好!

    0

  8. 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  9. 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time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217809, encodeId=42dd21e809df, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Jul 02 12:56:05 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-07-03 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  10. 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    2017-07-02 dhzzm

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