Cardiovasc Diabetol:内脏肥胖指数越高,糖尿病肾病风险越高!

2022-03-07 Nebula MedSci原创

内脏肥胖指数越高,2型糖尿病患者发生糖尿病肾病的风险越高!

2型糖尿病占所有糖尿病的90%,已成为全球重要的公共健康问题。预计2030年时,全球约有3.66亿糖尿病患者。糖尿病血管并发症已成为2型糖尿病患者死亡的主要原因。此外,血管并发症严重影响患者的生活质量,给医疗保健系统带来沉重的经济负担。

多项横断面研究报告了内脏肥胖指数(VAI)与糖尿病并发症之间的相关性,但是,VAI对并发症进展的影响仍未完全明确。本研究旨在在中国人群队列中评估VAI及中国人VAI(CVAI)与糖尿病肾病和糖尿病视网膜病变的相关性。

研究流程

自2013年至2014年期间,从北京健康管理队列中共招募了8948位2型糖尿病患者,随访至2019年12月31日。通过尿白蛋白/肌酐比值和估计的肾小球滤过率诊断肾病;使用眼底照相诊断视网膜病变。

VAI和CVAI与糖尿病肾病风险的相关性

受试患者平均53.35岁(SD 14.66),其中6154位(68.8%)是男性。在中位随访4.82年期间,有467位受试者患上了糖尿病肾病,90位受试者患上了糖尿病视网膜病变。VAI和CVAI水平每增加1 SD与糖尿病肾病风险升高显著相关,校正的风险比(HR)分别是1.127(95% CI 1.050-1.210)和1.165(1.003-1.353)。相反,根据混杂因素校正后,VAI和CVAI水平与糖尿病视网膜病变风险无显著相关性。

根据VAI或CVAI预测糖尿病肾病风险的敏感性

总之,VAI和CVAI是2型糖尿病患者发展成糖尿病肾病的风险独立相关,但与发生视网膜病变的风险无明显相关性。

 

原始出处:

Wu, Z., Yu, S., Kang, X. et al. Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population. Cardiovasc Diabetol 21, 32 (2022). https://doi.org/10.1186/s12933-022-01464-1

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1808492, encodeId=bc7f1808492ea, content=<a href='/topic/show?id=742f8191546' target=_blank style='color:#2F92EE;'>#肥胖指数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81915, encryptionId=742f8191546, topicName=肥胖指数)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Mon Apr 11 10:46:13 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761861, encodeId=faf91e618618b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 17 06:46:13 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939324, encodeId=7a0619393244b, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jun 26 00:46:13 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935640, encodeId=046a1935640ce, content=<a href='/topic/show?id=e08030504e4' target=_blank style='color:#2F92EE;'>#内脏肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30504, encryptionId=e08030504e4, topicName=内脏肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Fri Apr 29 17:46:13 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640075, encodeId=ba4f16400e556, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 21 09:46:13 CST 2023, time=2023-01-21, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1808492, encodeId=bc7f1808492ea, content=<a href='/topic/show?id=742f8191546' target=_blank style='color:#2F92EE;'>#肥胖指数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81915, encryptionId=742f8191546, topicName=肥胖指数)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Mon Apr 11 10:46:13 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761861, encodeId=faf91e618618b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 17 06:46:13 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939324, encodeId=7a0619393244b, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jun 26 00:46:13 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935640, encodeId=046a1935640ce, content=<a href='/topic/show?id=e08030504e4' target=_blank style='color:#2F92EE;'>#内脏肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30504, encryptionId=e08030504e4, topicName=内脏肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Fri Apr 29 17:46:13 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640075, encodeId=ba4f16400e556, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 21 09:46:13 CST 2023, time=2023-01-21, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1808492, encodeId=bc7f1808492ea, content=<a href='/topic/show?id=742f8191546' target=_blank style='color:#2F92EE;'>#肥胖指数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81915, encryptionId=742f8191546, topicName=肥胖指数)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Mon Apr 11 10:46:13 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761861, encodeId=faf91e618618b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 17 06:46:13 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939324, encodeId=7a0619393244b, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jun 26 00:46:13 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935640, encodeId=046a1935640ce, content=<a href='/topic/show?id=e08030504e4' target=_blank style='color:#2F92EE;'>#内脏肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30504, encryptionId=e08030504e4, topicName=内脏肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Fri Apr 29 17:46:13 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640075, encodeId=ba4f16400e556, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 21 09:46:13 CST 2023, time=2023-01-21, status=1, ipAttribution=)]
    2022-06-26 quxin068
  4. [GetPortalCommentsPageByObjectIdResponse(id=1808492, encodeId=bc7f1808492ea, content=<a href='/topic/show?id=742f8191546' target=_blank style='color:#2F92EE;'>#肥胖指数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81915, encryptionId=742f8191546, topicName=肥胖指数)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Mon Apr 11 10:46:13 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761861, encodeId=faf91e618618b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 17 06:46:13 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939324, encodeId=7a0619393244b, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jun 26 00:46:13 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935640, encodeId=046a1935640ce, content=<a href='/topic/show?id=e08030504e4' target=_blank style='color:#2F92EE;'>#内脏肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30504, encryptionId=e08030504e4, topicName=内脏肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Fri Apr 29 17:46:13 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640075, encodeId=ba4f16400e556, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 21 09:46:13 CST 2023, time=2023-01-21, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1808492, encodeId=bc7f1808492ea, content=<a href='/topic/show?id=742f8191546' target=_blank style='color:#2F92EE;'>#肥胖指数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81915, encryptionId=742f8191546, topicName=肥胖指数)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Mon Apr 11 10:46:13 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761861, encodeId=faf91e618618b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 17 06:46:13 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1939324, encodeId=7a0619393244b, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jun 26 00:46:13 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935640, encodeId=046a1935640ce, content=<a href='/topic/show?id=e08030504e4' target=_blank style='color:#2F92EE;'>#内脏肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30504, encryptionId=e08030504e4, topicName=内脏肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Fri Apr 29 17:46:13 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640075, encodeId=ba4f16400e556, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 21 09:46:13 CST 2023, time=2023-01-21, status=1, ipAttribution=)]

相关资讯

Diabetes Care:中科院学者:3成糖尿病死亡可以通过健康的生活方式预防!

在人群归因风险分析中,29.4%的死亡可归因于不良生活方式。

随访1万人超30年研究:中年就有三高等多发慢性病,晚年痴呆症风险高近5倍!

多病发病年龄与痴呆发病率之间的关系:前瞻性队列研究30年随访

每周只需半到1小时,心脏病、糖尿病、癌症、全因死亡率齐降10-17%!锻炼肌肉就是这么给力!

对队列研究的系统回顾和荟萃分析结果表明,加强肌肉活动与降低主要非传染性疾病的风险和死亡率有关!

Antioxidants (Basel):1型和2型糖尿病及不同程度肾功能不全患者维生素C状况与体重的关系

糖尿病是一种复杂的疾病,以慢性代谢紊乱和潜在的危及生命的并发症为特征。

Diabetes Care:潜伏性结核感染个体发生糖尿病的风险增加

潜伏性结核感染与糖尿病发病率增加有关。这些结果对占全球人口25%的潜伏性结核感染患者具有重要意义。

Lancet子刊:经济条件决定了该病的预后——全球年轻人糖尿病死亡率和趋势分析

联合国和世卫组织已将糖尿病确定为五种优先非传染性疾病(NCDs)之一。