JAMA Otolaryngol Head Neck Surg:慢性喉炎与鼻腔因素相关性研究

2019-08-27 AlexYang MedSci原创

过敏性喉炎由于其他原因引起的重叠临床表现而出现诊断不足的情况。鼻腔情况与慢性喉炎之间的相关性,包括过敏性喉炎,尚未见基于群体流行病学调查的相关报道。最近,有研究人员评估了慢性喉炎患病率与各种鼻腔症状和内窥镜发现的相关性,并鉴定了与慢性喉炎过敏性原因相关的特异性相关鼻腔因子。研究包括了11283名参与者,平均年龄(SD)为50.1(16.6)岁,其中6365(56.4%)名为女性。研究发现,总共有3

过敏性喉炎由于其他原因引起的重叠临床表现而出现诊断不足的情况。鼻腔情况与慢性喉炎之间的相关性,包括过敏性喉炎,尚未见基于群体流行病学调查的相关报道。

最近,有研究人员评估了慢性喉炎患病率与各种鼻腔症状和内窥镜发现的相关性,并鉴定了与慢性喉炎过敏性原因相关的特异性相关鼻腔因子。研究包括了11283名参与者,平均年龄(SD)为50.1(16.6)岁,其中6365(56.4%)名为女性。研究发现,总共有343名(3.0%)参与者通过喉镜检查诊断为慢性喉炎。慢性喉炎与更高的鼻炎症状比例(风险比 [OR], 1.54; 95%CI, 1.21-1.96)、前/后滴鼻液(OR, 2.03;95%CI, 1.38-2.98)、鼻塞(OR, 1.49;95%CI, 0.99-2.25)、内镜下见苍白粘膜(OR, 1.74;95%CI, 1.33-2.28)、粘液或脓液样分泌物(OR, 1.53;95%CI, 1.08-2.18)和中鼻道脓样分泌物(OR, 1.85;95%可信区间,1.19 - -2.88)相关,尤其是在女性参与者和年龄大于50岁的参与者中更为明显。亚群分析阐释了所有局域过敏性喉炎的参与者表现出了对粉尘螨敏感情况。在年龄小于50岁的参与者中,并且过敏性喉炎组(n=9)具有更高的鼻症状患病率(n=5;56%),非过敏性喉炎组中为12名中1名具有鼻炎症状,占比8%。

最后,研究人员指出,各种鼻腔因子与慢性喉炎的相关性在女性参与者和年龄不小于50岁的参与者中更为明显。尽管如此,慢性喉炎患者中的鼻症状与喉炎过敏性起因相关只在小于50岁的患者中存在。在年轻的成年人中,鼻症状的存在有助于考虑过敏性喉炎的存在。

原始出处:

Lee K, Young Kang C, Lee H et al. Association of Sinonasal Factors With Chronic Laryngitis in Korean Adults. JAMA Otolaryngol Head Neck Surg. 15 Aug 2019

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