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NEJM：胆固醇流出能力或可预测心脏病风险

2015-01-30 小田 译 医学论坛网

胆固醇流出能力心脏病风险
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近期发表于《新英格兰医学杂志》(The New England Journal of Medicine)的一项新研究表明，新的评估指标——胆固醇流出能力(cholesterol efflux capacity)可能用于预测心脏病。与标准评估高密度脂蛋白(HDL)相比，该研究结果提供了更佳的靶向治疗信息。如今，研究者们更倾向于评估HDL的功能性，而既往只是检测循环血液中的HDL水平。 HD

近期发表于《新英格兰医学杂志》(The New England Journal of Medicine)的一项新研究表明，新的评估指标——胆固醇流出能力(cholesterol efflux capacity)可能用于预测心脏病。与标准评估高密度脂蛋白(HDL)相比，该研究结果提供了更佳的靶向治疗信息。如今，研究者们更倾向于评估HDL的功能性，而既往只是检测循环血液中的HDL水平。

HDL处于动态变化中，它还有许多功能尚未被发现，其主要作用是将血管中的胆固醇转运至肝脏。研究者们利用新方法检测了超过3000例受试者的胆固醇外流能力，该项研究是多种族的基于人群的队列研究，即达拉斯心脏研究(Dallas Heart Study)。

达拉斯心脏研究显示，与标准检测相比，检测胆固醇外流能力可提供显著不同的信息。研究还显示，在胆固醇外流和心脏病风险之间存在着保护性的关系，即患者的胆固醇外流能力越大，他/她可能患心脏病、卒中或因心脏病而死亡的可能性越少。与传统的检测HDL方法相比，胆固醇外流的上述相关性更强。

我们都知道，高密度脂蛋白胆固醇(HDL—C)是一种好胆固醇，但研究者们并未发现针对HDL—C的有效治疗方法。烟酸可升高HDL—C水平达20-25%，CETP抑制剂升高的甚至更多，但都未减少心脏事件。因此研究者们在探索着HDL更多的功能，以便寻找减少心脏病风险的靶向治疗手段。

美国心脏学会(AHA)推荐，20岁及以上无心脏病的人群应每4至6年检测一次胆固醇水平，那些心脏病风险更高的人群检测频率应更高。

原始出处：

New measurement of HDL function provides information about cardiovascular risk


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    2016-04-16 1dea6088m20(暂无匿称)

    血清胆固醇水平与冠心病正相关

    0

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    2015-02-17 chinayinhan

    已阅

    0

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    2015-02-15 午夜星河

    你哈爱

    0

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    2015-02-01 mgqwxj

    #心脏病风险#

    0

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    2015-02-01 mgqwxj

    #心脏病风险#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=78805, encodeId=c2bae8805b3, content=血清胆固醇水平与冠心病正相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8231711773, createdName=1dea6088m20(暂无匿称), createdTime=Sat Apr 16 21:56:00 CST 2016, time=2016-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16221, encodeId=722516221ec, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 00:57:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15484, encodeId=b3801548412, content=你哈爱, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Sun Feb 15 13:57:00 CST 2015, time=2015-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559679, encodeId=748315596e91e, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Sun Feb 01 01:05:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565688, encodeId=e4df1565688ad, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Sun Feb 01 01:05:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615376, encodeId=535d16153e681, content=<a href='/topic/show?id=3b7983458f5' target=_blank style='color:#2F92EE;'>#胆固醇流出能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83458, encryptionId=3b7983458f5, topicName=胆固醇流出能力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=598719623817, createdName=1249894fm79暂无昵称, createdTime=Sun Feb 01 01:05:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14892, encodeId=c156148929e, content=新指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Jan 30 19:59:00 CST 2015, time=2015-01-30, status=1, ipAttribution=)]
    2015-02-01 1249894fm79暂无昵称

    #胆固醇流出能力#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=78805, encodeId=c2bae8805b3, content=血清胆固醇水平与冠心病正相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8231711773, createdName=1dea6088m20(暂无匿称), createdTime=Sat Apr 16 21:56:00 CST 2016, time=2016-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16221, encodeId=722516221ec, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 00:57:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15484, encodeId=b3801548412, content=你哈爱, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Sun Feb 15 13:57:00 CST 2015, time=2015-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559679, encodeId=748315596e91e, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Sun Feb 01 01:05:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565688, encodeId=e4df1565688ad, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Sun Feb 01 01:05:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615376, encodeId=535d16153e681, content=<a href='/topic/show?id=3b7983458f5' target=_blank style='color:#2F92EE;'>#胆固醇流出能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83458, encryptionId=3b7983458f5, topicName=胆固醇流出能力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=598719623817, createdName=1249894fm79暂无昵称, createdTime=Sun Feb 01 01:05:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14892, encodeId=c156148929e, content=新指标, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Jan 30 19:59:00 CST 2015, time=2015-01-30, status=1, ipAttribution=)]
    2015-01-30 lovetcm

    新指标

    0