Radiology:怎么调整频谱CT来评价肾损害呢?

2018-06-08 shaosai MedSci原创

本研究旨在探讨虚拟单能 (VM) 成像能量水平与微创肾损害检测灵敏度的关系。

本研究旨在探讨虚拟单能 (VM) 成像能量水平与微创肾损害检测灵敏度的关系。

材料和方法模拟非增强和对比增强肾实质分别配备含不同浓度碘的插入物 (范围, 0-1, 每毫升15毫克碘)。共有180例患者 (117 人; 平均年龄, 65.2±13.0 [标准差])和194例肾脏病变直径大于10毫米的患者(62例实性,132例囊性)进行了非增强单能量CT和增强双能量CT. 分别使用70、80、90和100keV来建立VM 成像数据集。对肾脏病变及其强化进行了测量。应用DeLong法测定肾损害的特征曲线下面积。

结果显示70keV的曲线下面积最高, 随能量增加到100keV,曲线下面积逐渐减小。模拟组的曲线下面积从 70keV的98% (95% 置信区间 [CI]:95, 100)下降到100keV的88% (95% CI:79, 96) (P = 0.004)。患者组的曲线下面积从70keV的96% (95% ci:94, 98) 下降到100keV的 79% (95% CI:71, 86) (P = 0.001)。在增强阈值为15HU的患者中, 实性肾损害的检测灵敏度从70keV的 91% ( 62例中有49例 [95% CI:78, 97]) 下降到 100keV的48% (62例中有33例 [95% CI:25, 71]) (P<0.05), 但其特异性没有大的变动 ,分别为70keV的93% [132 例中有120例{95% CI:87, 97}] 和100keV的 97% [132 例中有125例{95% CI:92, 99}]。

本研究说明随着 VM 成像能量的增加, 肾损害的诊断准确率降低。70keV的设置可以在灵敏度和特异性之间提供最佳平衡。

原始出处:

Schabel C, Patel B, Harring S. et al.Renal Lesion Characterization with Spectral CT: Determining the Optimal Energy for Virtual Monoenergetic Reconstruction.Radiology.DOI:10.1148/radiol.2018171657

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1754610, encodeId=45ea1e5461011, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Sat May 04 14:12:00 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322916, encodeId=cc8e32291669, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jun 10 05:58:37 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444386, encodeId=a3421444386f6, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Jun 09 16:12:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322440, encodeId=a597322440f4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TNV5cElot3tDNlyIMGic8HtYGcKD9cIvZR1TXRasIwjyib9BdYd3p4jcM75yvkr22FDhd6jseJmBOLaGyejic1vew/132, createdBy=fc402371135, createdName=润泽River, createdTime=Fri Jun 08 08:05:41 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322356, encodeId=a15132235699, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 08 03:37:05 CST 2018, time=2018-06-08, status=1, ipAttribution=)]
    2019-05-04 lq0313
  2. [GetPortalCommentsPageByObjectIdResponse(id=1754610, encodeId=45ea1e5461011, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Sat May 04 14:12:00 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322916, encodeId=cc8e32291669, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jun 10 05:58:37 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444386, encodeId=a3421444386f6, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Jun 09 16:12:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322440, encodeId=a597322440f4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TNV5cElot3tDNlyIMGic8HtYGcKD9cIvZR1TXRasIwjyib9BdYd3p4jcM75yvkr22FDhd6jseJmBOLaGyejic1vew/132, createdBy=fc402371135, createdName=润泽River, createdTime=Fri Jun 08 08:05:41 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322356, encodeId=a15132235699, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 08 03:37:05 CST 2018, time=2018-06-08, status=1, ipAttribution=)]
    2018-06-10 三生有幸9135

    学习一下谢谢

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1754610, encodeId=45ea1e5461011, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Sat May 04 14:12:00 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322916, encodeId=cc8e32291669, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jun 10 05:58:37 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444386, encodeId=a3421444386f6, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Jun 09 16:12:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322440, encodeId=a597322440f4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TNV5cElot3tDNlyIMGic8HtYGcKD9cIvZR1TXRasIwjyib9BdYd3p4jcM75yvkr22FDhd6jseJmBOLaGyejic1vew/132, createdBy=fc402371135, createdName=润泽River, createdTime=Fri Jun 08 08:05:41 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322356, encodeId=a15132235699, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 08 03:37:05 CST 2018, time=2018-06-08, status=1, ipAttribution=)]
    2018-06-09 huagfeg
  4. [GetPortalCommentsPageByObjectIdResponse(id=1754610, encodeId=45ea1e5461011, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Sat May 04 14:12:00 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322916, encodeId=cc8e32291669, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jun 10 05:58:37 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444386, encodeId=a3421444386f6, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Jun 09 16:12:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322440, encodeId=a597322440f4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TNV5cElot3tDNlyIMGic8HtYGcKD9cIvZR1TXRasIwjyib9BdYd3p4jcM75yvkr22FDhd6jseJmBOLaGyejic1vew/132, createdBy=fc402371135, createdName=润泽River, createdTime=Fri Jun 08 08:05:41 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322356, encodeId=a15132235699, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 08 03:37:05 CST 2018, time=2018-06-08, status=1, ipAttribution=)]
    2018-06-08 润泽River

    学习了.谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1754610, encodeId=45ea1e5461011, content=<a href='/topic/show?id=c781825606e' target=_blank style='color:#2F92EE;'>#肾损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82560, encryptionId=c781825606e, topicName=肾损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eaf036768149, createdName=lq0313, createdTime=Sat May 04 14:12:00 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322916, encodeId=cc8e32291669, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jun 10 05:58:37 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444386, encodeId=a3421444386f6, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Jun 09 16:12:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322440, encodeId=a597322440f4, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TNV5cElot3tDNlyIMGic8HtYGcKD9cIvZR1TXRasIwjyib9BdYd3p4jcM75yvkr22FDhd6jseJmBOLaGyejic1vew/132, createdBy=fc402371135, createdName=润泽River, createdTime=Fri Jun 08 08:05:41 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322356, encodeId=a15132235699, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Jun 08 03:37:05 CST 2018, time=2018-06-08, status=1, ipAttribution=)]
    2018-06-08 飛歌

    学习了很有用

    0

相关资讯

Lancet Neurol:B族维生素预防卒中? 然而...

B族维生素能够降低血浆总同型半胱氨酸(HCY)脓毒,可能对预防卒中有效。然而,维生素B12(cyanocobalamin)会降低肾功能,会增加肾功能损害患者的心血管事件风险。尽管早期的试验并未发现B族维生素能够降低卒中风险,但是这些结果可能和纳入了肾损害患者有关。在糖尿病肾病的患者中,维生素B12也是有害的,但是其降低肾功能正常患者的心血管事件。

FDA:抗击艾滋病的重磅武器来啦!

FDA批准,制药商吉利德科学公司生产的药物 Genvoya可以作为12岁及以上的HIV患者的治疗用药。Genvoya是固定剂量的Elvitegravir、cobicistat、emtricitabine和tenofovir alafenamide等药物的组合。FDA要求,药物的使用人群限于12岁及以上的患者,体重至少达到35公斤(77磅),之前从未针对艾滋病毒进行治疗过,或者艾滋病毒感染但病毒处于

AM J KIDNEY DIS:糖尿病前期血糖过高也会损害肾脏功能!

以往的研究表明,糖尿病是肾脏疾病的主要危险因素之一。大约30%的1-型糖尿病患者和10-40%的2-型糖尿病患者会发展为肾衰竭。近日,由北挪威大学医院肾脏科Toralf Melsom博士和他的研究团队在美国肾脏病杂志期刊上发表的一项最新的研究成果表明,在糖尿病前期,高于正常的血糖水平也可能会导致肾脏损害。Toralf Melsom博士与他的团队成员发现,在很久以前已经有人开始试图寻找糖尿病与肾损伤

避免小儿药物性肾损害的发生,这4大原则需谨记

严格掌握用药指征,防止滥用,是尽力避免儿童药物性肾病最有效的途径

嗜血细胞综合征并发血栓性微血管病肾损害一例

患者,女,15岁,学生,平素身体健康。

系统性红斑狼疮继发肾损害合并干燥综合征病例1例

患者,女性,70岁,2017年1月20日因间断眼睑及双下肢水肿4年、发热2周为主诉入院。