JCEM:长期暴露于环境空气污染与骨骼强度的关系

2021-07-19 MedSci原创 MedSci原创

长期暴露于空气污染与骨强度或骨质疏松症相关的证据很少,特别是在高污染的低收入和中等收入国家。关于空气污染与骨骼强度之间的关联是否在不同的骨骼强度分布下发生变化尚未明确。

长期暴露于空气污染与骨强度或骨质疏松症相关的证据很少,特别是在高污染的低收入和中等收入国家。关于空气污染与骨骼强度之间的关联是否在不同的骨骼强度分布下发生变化尚未明确。


 
近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员使用来自中国多民族队列的基线数据,调查了长期空气污染暴露与骨骼强度之间的关联。


研究人员使用多个线性模型来估计了空气污染与骨骼强度之间的关联,并使用分位数回归模型来探究这种关联在不同骨强度分布中的变化。研究人员使用空间统计模型评估每位参与者的PM1、PM2.5、PM10和NO2的3年平均浓度。研究人员使用定量超声测量的跟骨定量超声指数(QUI)衡量骨强度,QUI值越高表明骨强度越大。


该研究总共纳入了66598名参与者。研究人员分析发现3年平均PM1、PM2.5、PM10和NO2每增加10μg/m3,导致QUI分别变化-5.38个单位(95%CI:-6.17,-4.60)、-1.89个单位(95%CI:-2.33、-1.44)、-0.77个单位(95%CI:-1.08、-0.47)和-2.02个单位(95%CI:-2.32、-1.71)。此外,骨强度较高的人群可能更容易受到空气污染的影响。
 
由此可见,中国西南地区成年人长期暴露于PM1、PM2.5、PM10和NO2与骨强度下降显著相关。在骨强度较高的人群中,空气污染暴露对骨骼的不利影响更大。

原始出处:

Jialong Wu.et al.The Association between Long-term Exposure to Ambient Air Pollution and Bone Strength in China.JCEM.2021.https://doi.org/10.1210/clinem/dgab462

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    2021-12-17 smallant2015
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    2022-02-17 achengzhao
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    2021-07-19 1211c54em14(暂无昵称)

    学习了。新知识

    0

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