J Gastroenterol Hepatol:基线ZJU指数和**ZJU指数的变化能够独立预测中国人口发生NAFLD事件的风险

2018-02-01 MedSci MedSci原创

基线ZJU指数和绝对ZJU指数的变化能够独立预测中国人口发生NAFLD事件的风险。

随着生活条件的好转,生活方式的转变,非酒精性脂肪性肝病(NAFLD)能为继病毒性肝炎之后,第二大高发病率的肝病。用来评估非酒精性脂肪性肝病(NAFLD)风险的非侵入性方法,一直被广泛的研究。本研究的目的是分析ZJU指数和NAFLD疾病进展的相关性。

本研究纳入6310例最初未患NAFLD的患者。采用腹部超声诊断NAFLD。根据基线ZJU指数的不同,将其分为5个分段,根据5分段计算NAFLD发病率。采用Cox比例风险回归分析来计算NAFLD事件的风险。

在37705人年的随访过程中,共计1071例患者发生NALFD。基线ZJU指数呈线性,与NAFLD发病率呈正相关。基线不同ZJU指数参与者(根据ZJU指数分为5个区段),在随访过程中,每1000人年NAFLD的发生分别为5.53例,11.75例,23.77例,43.28例和85.60例。相对于基线ZJU指数在前1/5的患者,基线ZJU指数在2/5-5/5的患者,NAFLD发生的风险比分为为2.092 (1.458-3.002), 4.094 (2.942-5.698), 7.095 (5.167-9.742), 13.191 (9.684-17.968)。进一步的分析发现,随访中ZJU指数的变化也与NAFLD事件的风险独立相关。

基线ZJU指数和绝对ZJU指数的变化能够独立预测中国人口发生NAFLD事件的风险。

原始出处

Wang J, Ma L, Chen S, et al. Risk for the development of non-alcoholic fatty liver disease: a prospective study. J Gastroenterol Hepatol, 2018, Jan 30. doi: 10.1111/jgh.14105.

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    2018-04-22 lvygwyt2781
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    2018-02-26 许安
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    2018-02-03 gwc384

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