CCI:左心室纵向应变与主动脉狭窄转归相关

2012-10-03 高晓方译 医学论坛网

  美国学者的一项研究表明,在严重无症状性主动脉狭窄(AS)患者中左心室整体纵向应变(GLS)与患者转归具有相关性。论文于2012年9月24日在线发表于《循环:心血管影像》(Circ Cardiovasc Imaging)杂志。   此项研究共纳入伴有严重无症状性AS的79例患者[平均年龄为(77±12)岁]。测定斑点应变仪评估GLS。就心源性死亡和主动脉瓣置换(AVR)对患

  美国学者的一项研究表明,在严重无症状性主动脉狭窄(AS)患者中左心室整体纵向应变(GLS)与患者转归具有相关性。论文于2012年9月24日在线发表于《循环:心血管影像》(Circ Cardiovasc Imaging)杂志。

  此项研究共纳入伴有严重无症状性AS的79例患者[平均年龄为(77±12)岁]。测定斑点应变仪评估GLS。就心源性死亡和主动脉瓣置换(AVR)对患者进行随访。利用多变量Cox回归确认事件相关性。

  结果显示,随访(23±20)个月之后,3例受试者出现心源性死亡,49例接受AVR治疗。1、2和4年的无事件生存率分别为(72±5)%、(50±5)%和(24±5)%。GLS可预测死亡和AVR;主动脉瓣钙化范围、经主动脉峰压梯度、瓣膜动脉阻抗(Zva)和胸外科学会死亡预测风险(STS-PRMM)亦可预测。平均绝对GLS≤15%与显著超额死亡率相关,并且该指标可增加预测价值。

  链接:

Yingchoncharoen T, Gibby C, Rodriguez LL, Grimm RA, Marwick TH. Association of Myocardial Deformation with Outcome in Asymptomatic Aortic Stenosis with Normal Ejection Fraction.  Circ Cardiovasc Imaging. 2012 Sep 24

  



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