BMC Anesthesiol:七氟烷与异丙酚-瑞芬太尼相比对老年冠心病患者心脏保护作用的随机对照研究

2017-11-17 佘玉琦 “罂粟花”微信号

非心脏手术患者尤其是并存冠心病的老年患者,七氟醚的心脏保护作用仍存质疑。我们假设在非心脏手术中长时间吸入七氟烷可以改善患者的心肌损伤。

背景与目的:非心脏手术患者尤其是并存冠心病的老年患者,七氟醚的心脏保护作用仍存质疑。我们假设在非心脏手术中长时间吸入七氟烷可以改善患者的心肌损伤。

方  法:采用随机前瞻性研究,将121例冠心病老年患者随机分为两组,分别用七氟烷(S组)吸入或异丙酚-瑞芬太尼(PR组)进行麻醉维持。麻醉诱导前(T0),麻醉后8h(T1),24h(T2)测量血清心肌肌钙蛋白I(cTnI)和脑钠肽(BNP)。记录围手术期心输出量和并发症,术后随访3个月。

结  果:CTnI和BNP值组间差异均无统计学意义,但是S组术后24h的cTnI值曲线下的面积较小。在研究期间,PR组心脏输出量较低,去氧肾上腺素使用较多(P <0.05)。

结  论:与丙泊酚组相比,七氟醚对老年冠心病患者的心肌保护无益,但在手术期间七氟醚可维持血液动力学稳定性。

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CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070119, encodeId=044520e01195d, content=<a href='/topic/show?id=60495142057' target=_blank style='color:#2F92EE;'>#心脏保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51420, encryptionId=60495142057, topicName=心脏保护作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Fri Aug 03 04:02:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384807, encodeId=653c138480e39, content=<a href='/topic/show?id=93918690e81' target=_blank style='color:#2F92EE;'>#芬太尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86907, encryptionId=93918690e81, topicName=芬太尼)], attachment=null, 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channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68740, encryptionId=568068e40fa, topicName=瑞芬太尼)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2a92531888, createdName=qidongfanjian, createdTime=Sun Nov 19 05:02:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447711, encodeId=f5e3144e711ca, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Sun Nov 19 05:02:00 CST 2017, time=2017-11-19, status=1, ipAttribution=)]
    2017-11-19 xue8602
  8. 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  9. 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