Sci Transl Med:抗氧化剂可加快肿瘤细胞转移速度

2015-10-10 MedSci 译 MedSci原创

当我们想到抗氧化的作用时,我们经常把它与民众健康和充满活力等联系在一起。你是否认为,水果和蔬菜中富含抗氧化剂是一件喜大普奔的好事情?然而,在瑞典哥德堡大学萨尔格学院的研究人员对老鼠进行的一项新近研究表明,抗氧化剂可加快黑色素瘤患者在体内的转移速度,并使转移速度加倍。这项研究发表在《Science Translational Medicine》杂志。 在所有皮肤癌患者中,黑色素瘤患者所占比重不足2%

当我们想到抗氧化的作用时,我们经常把它与民众健康和充满活力等联系在一起。你是否认为,水果和蔬菜中富含抗氧化剂是一件喜大普奔的好事情?然而,在瑞典哥德堡大学萨尔格学院的研究人员对老鼠进行的一项新近研究表明,抗氧化剂可加快黑色素瘤患者在体内的转移速度,并使转移速度加倍。这项研究发表在Science Translational Medicine杂志。 

在所有皮肤癌患者中,黑色素瘤患者所占比重不足2%,但是却十分致命,病死率极高。在所有癌症中,皮肤癌很常见。

在当今社会中,人们普遍使用抗氧化剂用于预防癌症和营养补充剂。大家都认为抗氧化剂对人体极为有益,是预防氧气对人体有不良影响的物质。有研究表明,它是能帮助捕获并中和自由基,从而祛除自由基对人体损害的一类物质。但是在肺癌研究中,有研究人员表示,抗氧化剂可加速肿瘤的转移和复发,这引起了医学界的重视,因此研究人员开始进一步探究抗氧化剂对肿瘤的作用。

Martin Bergö教授领导的研究人员指出,抗氧化剂的作用对黑色素瘤患者十分重要,因为黑色素瘤细胞对自由基尤其敏感。

在对恶性黑色素瘤患者的细胞进行培养实验后,研究人员发现,保护健康细胞免受自由基的抗氧化剂,居然可以把它们变成恶性肿瘤。一旦恶性肿瘤形成,抗氧化剂也会像保护正常细胞一样保护肿瘤细胞。且抗氧化剂促使黑色素瘤细胞加速转移,转移速度未使用抗氧化剂时的2倍。

“皮肤和防晒乳液中有时含有β-胡萝卜素和维生素E,这两种物质相当于抗氧化剂,可能影响恶性黑色素瘤细胞的作用,”Bergo教授说道,“抗氧化剂可提高肿瘤细胞转移的能力,致命的是,这常常是导致肿瘤患者死亡的主要原因。因为通常不发生转移的肿瘤细胞常常不构成危害,如果得以有效清除,则不会引起机体出现致命危害。因此,肿瘤患者应避免食用抗氧化剂补充剂。”

原始出处:

Antioxidants: helpful or harmful for melanoma?MNT,9,Oct,2015

Antioxidants can increase melanoma metastasis in mice, Martin Bergö et al., Science Translational Medicine,7 Oct,2015

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    2016-03-11 贝儿

    迷茫了

    0

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    2015-12-15 bsmagic9140
  4. 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channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Oct 12 05:20:00 CST 2015, time=2015-10-12, status=1, ipAttribution=)]
    2015-12-09 三三五五

    白血病患者不能用Vitc了?

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067170, encodeId=1613206e1701c, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Apr 19 04:20:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42086, encodeId=959c42086ed, content=以前总是看到在化疗期间服用抗氧化剂可以减少副作用的发生。现在, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, 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  6. 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    2015-10-31 byzl

    以前总是看到在化疗期间服用抗氧化剂可以减少副作用的发生。现在

    0

  7. 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  8. 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    2015-10-12 zz72
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