CHEST:COPD患者中哮喘-COPD重叠综合征的定义

2016-01-21 fsy 译 MedSci原创

哮喘-COPD重叠综合征(ACOS)最近已被国际指南进行了描述。指南建议使用这两种疾病的常用的特点进行逐步的方法来诊断,虽然其临床应用是非常困难的。该研究的目的是确定ACOS患者,研究人员对具有良好的COPD特点的队列并被随访长达1年的患者进行了分析。研究人员评估了COPD队列中与哮喘相关的具体特点的存在,分为主要标准(支气管扩张试验>400mL,15%和哮喘既往病史)和次要标准(血液中嗜酸

哮喘-COPD重叠综合征(ACOS)最近已被国际指南进行了描述。指南建议使用这两种疾病的常用的特点进行逐步地诊断,虽然在临床上逐步诊断是困难的。

该研究的目的是确定ACOS患者,研究人员对具有良好的COPD特点的队列并被随访长达1年的患者进行了分析。研究人员评估了COPD队列中与哮喘相关的具体特点的存在,分为主要标准(支气管扩张试验>400mL,15%和哮喘既往病史)和次要标准(血液中嗜酸性粒细胞>5%,IgE>100 IU/mL,或两个独立的支气管舒张试验>200mL和12%)。研究人员通过一个主要标准或两个次要标准的存在定义ACOS。研究人员在长达1年的随访中对有和无ACOS标准患者的基线特征、健康状况(COPD评估测试[CAT])、BMI、气流阻塞、呼吸困难、运动能力(BODE)指数、病情加重率和死亡率进行了比较。

共有831例COPD患者被纳入分析,125例(15%)符合ACOS标准,其中98.4%的患者1年后持续这些标准。ACOS患者大多为男性(81.6%),有轻度至中度疾病症状的患者为67%,正在接受吸入糖皮质激素的患者为63.2%。1年的随访后,基线特征没有显著差异(P<0.05),只有非ACOS的COPD患者生存恶化。

最新指南所提出的ACOS标准目前在COPD队列中15%的患者中出现,这些患者的1年预后比临床疑似COPD患者但没有ACOS标准的患者要更好。

原始出处:

Borja G. Cosio,Joan B. Soriano,Jose Luis López-Campos,et al.Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort,CHEST,2016.1.19

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    2018-05-08 871538379

    学习了 非常感谢

    0

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    2016-08-16 Smile2680
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    2016-03-15 zta

    前两天刚看了这篇文章,有个地方没看懂

    0

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    2016-02-13 ssummer

    已阅

    0

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    2016-01-27 李继凯

    好好学习一下

    0

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    2016-01-26 sundyli

    估计能写进指南了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=313115, encodeId=beaf3131155d, content=学习了 非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Tue May 08 07:41:28 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929238, encodeId=1a0c192923854, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Aug 16 04:05:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050528, encodeId=7b0d205052884, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Mar 19 06:05:00 CST 2016, time=2016-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=69528, encodeId=fb7a6952819, content=前两天刚看了这篇文章,有个地方没看懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160315/IMG56E7F31C448279358.jpg, createdBy=d4f01700601, createdName=zta, createdTime=Tue Mar 15 19:33:00 CST 2016, time=2016-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64131, encodeId=2b3f641312d, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Sat Feb 13 09:55:00 CST 2016, time=2016-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61079, encodeId=bf7f610e9c6, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 18:31:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60021, encodeId=dc1960021e1, content=估计能写进指南了, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Tue Jan 26 19:53:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59952, encodeId=f17759952ea, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:16:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59953, encodeId=6b61599537d, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:16:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58979, encodeId=d616589e9ca, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Sun Jan 24 13:16:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-26 doctording1

    这篇文章有一定深度

    0

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    2016-01-26 doctording1

    是一篇不错的文章

    0

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    2016-01-24 卡莲

    0

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