Eur Urol:经尿道膀胱肿瘤切除术治疗非肌层浸润性膀胱癌质量和效果的改善

2020-08-08 AlexYang MedSci原创

非肌层浸润性膀胱癌(NMIBC)的临床结果部分的由起始干预手段的质量来决定。最近,有研究人员评估了与经尿道膀胱肿瘤切除(TURBT)相关的特异性质量指标(QIs)的符合性情况,并了解在引入QPI(质量

非肌层浸润性膀胱癌(NMIBC)的临床结果部分的由起始干预手段的质量来决定。最近,有研究人员评估了与经尿道膀胱肿瘤切除(TURBT)相关的特异性质量指标(QIs)的符合性情况,并了解在引入QPI(质量表现指标)计划后NMIBC的临床结果情况。

患者统计资料

研究包括了4246名新膀胱癌(BC)患者,67%(2029/3023)名NMIBC患者中使用了TURBT术后单次滴注丝裂霉素C(SPI-MMC)。在1860名经历TURBT的NMIBC患者中,首次膀胱镜检查复发率(RRFFC)、残癌率和re-TURBT的pT2比例分别为13% (116/888)、33% (212/653)和2.9% (19/653)。SPI-MMC与更低的RRFFC相关,且与所有的变量,包括住院容量和手术医生无关。活检样本中逼尿肌(DM)的存在能够使pT1癌症中疾病残留可能性减少一半。研究的主要限制因素为缺少用于比较的预QPI引入队列。

首次随访膀胱镜检复发率和早期re-TURBT癌残留情况

最后,研究人员指出,QI计划在苏格兰的实施提高了TURBT的质量,并且与真实世界中与低对水平早期复发/残留癌和精准的病理分期相关。

原始出处:

Paramananthan Mariappan, Allan Johnston, Luisa Padovani et al. Enhanced Quality and Effectiveness of Transurethral Resection of Bladder Tumour in Non-muscle-invasive Bladder Cancer: A Multicentre Real-world Experience from Scotland's Quality Performance Indicators Programme. Eur Urol. Jul 2020

 

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    2021-04-13 lifestar
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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25915252522, createdName=147e4799m34暂无昵称, createdTime=Tue Oct 13 23:56:25 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481206, encodeId=00de1481206a2, content=<a href='/topic/show?id=2e2399635a4' target=_blank style='color:#2F92EE;'>#非肌层浸润性膀胱癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99635, encryptionId=2e2399635a4, topicName=非肌层浸润性膀胱癌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 10 05:48:58 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039987, 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level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Aug 08 15:09:24 CST 2020, time=2020-08-08, status=1, ipAttribution=)]
  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25915252522, createdName=147e4799m34暂无昵称, createdTime=Tue Oct 13 23:56:25 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481206, encodeId=00de1481206a2, content=<a href='/topic/show?id=2e2399635a4' target=_blank style='color:#2F92EE;'>#非肌层浸润性膀胱癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99635, encryptionId=2e2399635a4, topicName=非肌层浸润性膀胱癌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 10 05:48:58 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039987, 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level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Aug 08 15:09:24 CST 2020, time=2020-08-08, status=1, ipAttribution=)]
  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25915252522, createdName=147e4799m34暂无昵称, createdTime=Tue Oct 13 23:56:25 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481206, encodeId=00de1481206a2, content=<a href='/topic/show?id=2e2399635a4' target=_blank style='color:#2F92EE;'>#非肌层浸润性膀胱癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99635, encryptionId=2e2399635a4, topicName=非肌层浸润性膀胱癌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 10 05:48:58 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039987, 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level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Aug 08 15:09:24 CST 2020, time=2020-08-08, status=1, ipAttribution=)]
    2020-10-13 147e4799m34暂无昵称

    有用

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25915252522, createdName=147e4799m34暂无昵称, createdTime=Tue Oct 13 23:56:25 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481206, encodeId=00de1481206a2, content=<a href='/topic/show?id=2e2399635a4' target=_blank style='color:#2F92EE;'>#非肌层浸润性膀胱癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99635, encryptionId=2e2399635a4, topicName=非肌层浸润性膀胱癌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 10 05:48:58 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039987, encodeId=36d7103998e7c, content=膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Aug 08 17:48:58 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047141, encodeId=cde3104e14137, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 08 17:48:58 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806933, encodeId=0fe380693317, content=学习,很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Aug 08 15:09:24 CST 2020, time=2020-08-08, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1769168, encodeId=273e1e6916895, content=<a href='/topic/show?id=ebef4e52844' target=_blank style='color:#2F92EE;'>#尿道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47528, encryptionId=ebef4e52844, topicName=尿道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b63c37986505, createdName=lifestar, createdTime=Tue Apr 13 22:48:58 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700803, encodeId=372c1e00803d5, content=<a href='/topic/show?id=8f36858051e' target=_blank style='color:#2F92EE;'>#膀胱肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85805, encryptionId=8f36858051e, topicName=膀胱肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25915252522, createdName=147e4799m34暂无昵称, createdTime=Tue Oct 13 23:56:25 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481206, encodeId=00de1481206a2, content=<a href='/topic/show?id=2e2399635a4' target=_blank style='color:#2F92EE;'>#非肌层浸润性膀胱癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99635, encryptionId=2e2399635a4, topicName=非肌层浸润性膀胱癌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 10 05:48:58 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039987, encodeId=36d7103998e7c, content=膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Aug 08 17:48:58 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047141, encodeId=cde3104e14137, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 08 17:48:58 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806933, encodeId=0fe380693317, content=学习,很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Aug 08 15:09:24 CST 2020, time=2020-08-08, status=1, ipAttribution=)]
    2020-08-08 留走人康

    膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1769168, encodeId=273e1e6916895, content=<a href='/topic/show?id=ebef4e52844' target=_blank style='color:#2F92EE;'>#尿道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47528, encryptionId=ebef4e52844, topicName=尿道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b63c37986505, createdName=lifestar, createdTime=Tue Apr 13 22:48:58 CST 2021, time=2021-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700803, encodeId=372c1e00803d5, content=<a href='/topic/show?id=8f36858051e' target=_blank style='color:#2F92EE;'>#膀胱肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85805, encryptionId=8f36858051e, topicName=膀胱肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25915252522, createdName=147e4799m34暂无昵称, createdTime=Tue Oct 13 23:56:25 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481206, encodeId=00de1481206a2, content=<a href='/topic/show?id=2e2399635a4' target=_blank style='color:#2F92EE;'>#非肌层浸润性膀胱癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99635, encryptionId=2e2399635a4, topicName=非肌层浸润性膀胱癌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 10 05:48:58 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039987, encodeId=36d7103998e7c, content=膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Aug 08 17:48:58 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047141, encodeId=cde3104e14137, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 08 17:48:58 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806933, encodeId=0fe380693317, content=学习,很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Aug 08 15:09:24 CST 2020, time=2020-08-08, status=1, ipAttribution=)]
    2020-08-08 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25915252522, createdName=147e4799m34暂无昵称, createdTime=Tue Oct 13 23:56:25 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481206, encodeId=00de1481206a2, content=<a href='/topic/show?id=2e2399635a4' target=_blank style='color:#2F92EE;'>#非肌层浸润性膀胱癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99635, encryptionId=2e2399635a4, topicName=非肌层浸润性膀胱癌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 10 05:48:58 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039987, encodeId=36d7103998e7c, content=膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Aug 08 17:48:58 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047141, encodeId=cde3104e14137, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Aug 08 17:48:58 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806933, encodeId=0fe380693317, content=学习,很好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Aug 08 15:09:24 CST 2020, time=2020-08-08, status=1, ipAttribution=)]
    2020-08-08 ms3000000449926787

    学习,很好!

    0

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之前的研究发现,从膀胱肿瘤患者中分离出来的尿液样本中的微生物群与健康对照尿液相比,一些细菌属的组成风度显著增加。最近,有研究人员比较了膀胱癌患者和正常对照中,癌症组织样本和尿液样本中的微生物群组成情况

男性,无痛性肉眼血尿1年,请诊断!

尿潜血:++2.0mg/L;尿红细胞:330/ul;红细胞1543.70(0-25);尿白细胞:95/ul;尿蛋白:+300mg/L;尿细菌培养:—;碱性磷酸酶:200U/L(45-125);CPR:

Eur Urol:T1膀胱癌不同肿瘤亚型的鉴定

T1期膀胱癌在所有非肌层浸润性膀胱癌(NMIBCs)中进展和复发率最高。大多数T1期癌症用卡介苗(BCG)治疗,但许多患者会进展或复发,甚至有些T1期患者会死于膀胱癌。典型的侵袭性的肿瘤可以通过早期膀

Sci Rep:膀胱癌患者中的循环蛋白组特征用于开发生物标记

临床相关早期诊断和预后蛋白生物标记的鉴定对最优化治疗效果和预防癌症恶化是非常必要的。最近,有研究人员确定了是否血浆蛋白异常可以作为膀胱癌早期诊断的一个替代工具。