Int Wound J:白藜芦醇对促进皮肤伤口愈合、减小疤痕、延迟皮肤老化

2022-01-11 MedSci原创 MedSci原创

白藜芦醇属于多酚中的茋类化合物,是一种有名的抗氧化剂,具有多种有益健康的特性。多项研究结果显示,白藜芦醇具有抗氧化、抗炎和细胞保护作用有关。

白藜芦醇属于多酚中的茋类化合物,是一种有名的抗氧化剂,具有多种有益健康的特性。多项研究结果显示,白藜芦醇具有抗氧化、抗炎和细胞保护作用有关。有研究推测,白藜芦醇的这些不同作用可能参与了皮肤伤口愈合、疤痕和皮肤(光)老化。近日,发表于Int Wound J的研究探究了白藜芦醇在伤口愈合、疤痕和皮肤光老化方面的效果。

研究人员进行了系统回顾,并在数据库PubMed中搜索了相关文献,收集2020年11月28日之前收录的关于白藜芦醇对伤口愈合、疤痕和皮肤(光)老化的影响的英文文章。

结果,研究人员共检索了826项研究,但最终只有41项研究符合纳入标准。分析结果显示,白藜芦醇可能是一种可行的治疗方法,可以促进伤口愈合,抵制过度的疤痕生长,甚至还可防止皮肤的光老化。机制研究结果显示,白藜芦醇可通过降低氧化应激水平对成纤维细胞有保护作用。另外,白藜芦醇的促血管生成特性与其促进伤口愈合的作用密切相关。白藜芦醇的抗菌和抗真菌特性也会在创口处诱导免疫刺激作用,因此白藜芦醇可能是一种有希望的对抗皮肤感染的药物。

综上所述,该研究结果表明,白藜芦醇代表了一种有趣和有前途的新疗法,但为了证实白藜芦醇的相关效果,需要更多基于证据的体外和体内研究,进一步调查和改善白藜芦醇的皮肤药代动力学及其临床相关性。

 

原始出处:

 

Andrzej Hecker, et al., The impact of resveratrol on skin wound healing, scarring, and aging. Int Wound J. 2022 Jan;19(1):9-28. doi: 10.1111/iwj.13601.  

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    2022-01-12 HinsMax

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白蛋白尿是糖尿病肾病(DN)最重要的指标。白藜芦醇是一种存在于葡萄皮和红葡萄酒中的天然化合物,具有抗氧化作用。本研究旨在评估白藜芦醇对DN的影响。

Clin Interv Aging:姜黄素联合白藜芦醇有益于慢性肾病和铁超载荷的患者

营养不良在血液透析患者中很常见,与发病率和死亡率密切相关。为了评价补充白藜芦醇和姜黄素十二周对慢性肾脏病和铁负荷过重的血液透析患者骨质和肌肉质量的恢复以及蛋白质氧化、脂质过氧化的影响,我们进行了随机、

Phytother Res:补充白藜芦醇对2型糖尿病患者心脏代谢危险因素的影响

本研究旨在评估微粉化白藜芦醇补充剂对2型糖尿病(T2DM)患者血糖状态,脂质分布和身体成分的影响。

Mol Immunol: 白藜芦醇介导的SIRT1激活能够减弱卵清蛋白诱导的过敏性鼻炎

白藜芦醇(RSV)是一种具有抗炎症效果的多酚物质。而RSV对过敏性鼻炎(AR)影响情况仍旧不清楚。

World Allergy Organ J:白藜芦醇的抗过敏和抗炎作用研究

过敏性鼻炎(AR)是一种由鼻部IgE介导的I型超敏反应。硫氧杂环蛋白(TXNIP)在产生活性氧(ROS)的过程中起着关键的作用。白藜芦醇是一种TXNIP抑制剂。尽管如此,其在AR中的作用和机制仍不确定

Int J Vitam Nutr Res:白藜芦醇并不会降低非酒精性脂肪肝患者动脉粥样硬化的风险

心血管疾病(CVD)是导致非酒精性脂肪性肝病(NAFLD)患者死亡的主要原因。白藜芦醇是一种天然的多酚化合物,以其抗氧化和抗动脉粥样硬化的特性而闻名,有研究显示白藜芦醇可降低非酒精性脂肪肝患者的CVD