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仅接受一次软式乙状结肠镜筛查预防结直肠癌的多中心随机对照试验

2011-05-06 MedSci原创 MedSci原创

乙状结肠镜筛查结直肠癌
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出处：Lancet. 2010 May 8; 375(9726):1624-33 作者：Atkin WS, Edwards R, Kralj-Hans I, Wooldrage K, Hart AR, Northover JM, Parkin DM, Wardle J, Duffy SW, Cuzick JPMID：20430429译者： F1000因子：12 评级：必读  &nb

出处：Lancet. 2010 May 8; 375(9726):1624-33 作者：Atkin WS, Edwards R, Kralj-Hans I, Wooldrage K, Hart AR, Northover JM, Parkin DM, Wardle J, Duffy SW, Cuzick JPMID：20430429译者： F1000因子：12 评级：必读     背景：      结直肠癌是全球第三大最常见的癌症，死亡率很高。我们假设，55岁至64岁人群仅进行1次软式乙状结肠镜检查可明显降低结直肠癌的发病率和死亡率。     方法：      在英国14个中心进行随机对照试验。170,432名此前接受调查问卷表示愿意进行筛查的男性和女性纳入研究，随机分为干预组（提供软式乙状结肠镜检查）或对照组（不联系）。通过生成连续数字进行随机化，分为12个区组，按照研究中心、医疗实践和家庭类型进行分层。主要终点是结

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    2011-09-04 amyloid

    #对照#

    0

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    2012-02-22 luoxiaog

    #多中心#

    0

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    2011-06-08 般若傻瓜

    #对照试验#

    0

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    2011-05-08 lisa438

    #随机对照试验#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1775248, encodeId=aaa61e7524833, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Sun Sep 04 00:25:00 CST 2011, time=2011-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903886, encodeId=a2991903886a8, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Wed Feb 22 20:25:00 CST 2012, time=2012-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987151, encodeId=9c3b198e15134, content=<a href='/topic/show?id=bac5466546c' target=_blank style='color:#2F92EE;'>#对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46654, encryptionId=bac5466546c, topicName=对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Jun 08 00:25:00 CST 2011, time=2011-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296141, encodeId=65b2129614134, content=<a href='/topic/show?id=7591984530b' target=_blank style='color:#2F92EE;'>#随机对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98453, encryptionId=7591984530b, topicName=随机对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434388, encodeId=eb0c14343885f, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452554, encodeId=69fa1452554ef, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625759, encodeId=b7521625e59ea, content=<a href='/topic/show?id=3d7423411e7' target=_blank style='color:#2F92EE;'>#乙状结肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23411, encryptionId=3d7423411e7, topicName=乙状结肠镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=018620859641, createdName=waiwai3037, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=)]
    2011-05-08 zhouqu_8

    #肠镜#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1775248, encodeId=aaa61e7524833, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Sun Sep 04 00:25:00 CST 2011, time=2011-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903886, encodeId=a2991903886a8, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Wed Feb 22 20:25:00 CST 2012, time=2012-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987151, encodeId=9c3b198e15134, content=<a href='/topic/show?id=bac5466546c' target=_blank style='color:#2F92EE;'>#对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46654, encryptionId=bac5466546c, topicName=对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Jun 08 00:25:00 CST 2011, time=2011-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296141, encodeId=65b2129614134, content=<a href='/topic/show?id=7591984530b' target=_blank style='color:#2F92EE;'>#随机对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98453, encryptionId=7591984530b, topicName=随机对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434388, encodeId=eb0c14343885f, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452554, encodeId=69fa1452554ef, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625759, encodeId=b7521625e59ea, content=<a href='/topic/show?id=3d7423411e7' target=_blank style='color:#2F92EE;'>#乙状结肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23411, encryptionId=3d7423411e7, topicName=乙状结肠镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=018620859641, createdName=waiwai3037, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=)]
    2011-05-08 crystal0564

    #结直肠#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1775248, encodeId=aaa61e7524833, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Sun Sep 04 00:25:00 CST 2011, time=2011-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903886, encodeId=a2991903886a8, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Wed Feb 22 20:25:00 CST 2012, time=2012-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987151, encodeId=9c3b198e15134, content=<a href='/topic/show?id=bac5466546c' target=_blank style='color:#2F92EE;'>#对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46654, encryptionId=bac5466546c, topicName=对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Jun 08 00:25:00 CST 2011, time=2011-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296141, encodeId=65b2129614134, content=<a href='/topic/show?id=7591984530b' target=_blank style='color:#2F92EE;'>#随机对照试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98453, encryptionId=7591984530b, topicName=随机对照试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434388, encodeId=eb0c14343885f, content=<a href='/topic/show?id=95de81e4889' target=_blank style='color:#2F92EE;'>#肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81748, encryptionId=95de81e4889, topicName=肠镜)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452554, encodeId=69fa1452554ef, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625759, encodeId=b7521625e59ea, content=<a href='/topic/show?id=3d7423411e7' target=_blank style='color:#2F92EE;'>#乙状结肠镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23411, encryptionId=3d7423411e7, topicName=乙状结肠镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=018620859641, createdName=waiwai3037, createdTime=Sun May 08 11:25:00 CST 2011, time=2011-05-08, status=1, ipAttribution=)]
    2011-05-08 waiwai3037

    #乙状结肠镜#

    0