存在合并症腹膜透析者预后差

2012-04-10 范振光 中国血液净化

  最近,北京大学第三医院肾脏内科、首都医科大学附属北京世纪坛医院干部医疗科的研究人员的一项研究显示,存在合并症的腹膜透析患者在透析过程中可能伴有更多的炎症状态和营养不良,且预后较差,合并症指数可以预测腹膜透析患者的预后。该研究发表于2012年第2期《中国血液净化》。       该研究旨在探讨合并症与腹膜透析患者炎症、营养状况以及预后的关系。     

  最近,北京大学第三医院肾脏内科、首都医科大学附属北京世纪坛医院干部医疗科的研究人员的一项研究显示,存在合并症的腹膜透析患者在透析过程中可能伴有更多的炎症状态和营养不良,且预后较差,合并症指数可以预测腹膜透析患者的预后。该研究发表于2012年第2期《中国血液净化》。
  合并症 腹膜透析 预后     该研究旨在探讨合并症与腹膜透析患者炎症、营养状况以及预后的关系。     周晓玲等研究人员选择腹膜透析患者202例人,记录患者进入腹膜透析时和腹膜透析后合并症发生状况以及截止至2010年8月31日前的转归。使用Charlson合并症指数(charlson comorbidity index,CCI)并把患者分为无合并症组、低合并症组和高合并症组,分析比较3组患者的炎症状况、营养水平以及转归情况。     结果显示,低合并症组和高合并症组与无合并症组相比主观综合性营养评估法(SGA)评估的营养不良发生率、血超敏C反应蛋白(hsCRP)水平均显著增加,血白蛋白、瘦体质量(LBM)、瘦体质量百分比(%LBM)、标准化蛋白质相当总氮表现率(nPNA)均显著降低。Kaplan-Meier分析显示,高合并症组和低合并症组患者的死亡率显著高于无合并症组。Cox多元回归分析显示,CCI、年龄、SGA、%LBM是影响患者预后的独立危险因素。

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    2012-04-12 xuyong530