Int J Cancer:前列腺癌 vs 乳腺癌的发病率和死亡率表明,前列腺癌正在被过度诊断

2017-08-31 MedSci MedSci原创

全球乳腺癌发病率自20世纪70年代末开始一直呈上升趋势。美国8名妇女一生中就会有1人患乳腺癌。中国不是乳腺癌的高发国家,但不宜乐观,近年我国乳腺癌发病率的增长速度却高出高发国家1~2个百分点。2012年我国肿瘤登记地区前列腺癌发病率为9.92/10万,列男性恶性肿瘤发病率的第6位。发病年龄在55岁前处于较低水平,55岁后逐渐升高,发病率随着年龄的增长而增长,高峰年龄是70~80岁。家族遗传型前列腺

全球乳腺癌发病率自20世纪70年代末开始一直呈上升趋势。美国8名妇女一生中就会有1人患乳腺癌。中国不是乳腺癌的高发国家,但不宜乐观,近年我国乳腺癌发病率的增长速度却高出高发国家1~2个百分点。

2012年我国肿瘤登记地区前列腺癌发病率为9.92/10万,列男性恶性肿瘤发病率的第6位。发病年龄在55岁前处于较低水平,55岁后逐渐升高,发病率随着年龄的增长而增长,高峰年龄是70~80岁。家族遗传型前列腺癌患者发病年龄稍早,年龄≤55岁的患者占43%。但是,近几十年来,前列腺癌和乳腺癌患者的管理发生了很大的变化。

为了解释四个北欧国家中在不同年龄段和病程时,前列腺癌和乳腺癌发病率和死亡率的模式,研究人员设计并完成了该研究。

研究人员从NORDCAN数据库获得1975-2013年间,前列腺癌和乳腺癌的发病率和死亡率数据。研究人员使用连接点的回归模型确定变化的趋势。

研究人员发现,前列腺癌发病率显著高于乳腺癌发病率。从1990年代中期开始,四个北欧国家(丹麦、芬兰、挪威、)中75岁以下患者的前列腺癌/乳腺癌相关的死亡率都有所下降。

低于50岁的女性中,在1985-1989年间,乳腺癌的死亡率相对降低;在2009-2013年间,乳腺癌的死亡率最高;乳腺癌死亡率的降低,在芬兰最小,为38%;在丹麦最大,为55%。在55-74岁的男性中,在除了丹麦之外的所有国家中,前列腺癌的死亡率下降都比乳腺癌死亡率的下降更多,从14%(丹麦)到39%(挪威)。

1990年代中期开始的低于常规筛查年龄的女性中乳腺癌死亡率的大幅下降和丹麦两种癌症的死亡率的下降都与与乳房X光检查和PSA检测的改善有关。

死亡率的降低水平相似,但前列腺癌发病率仍比乳腺癌增加的更多,这表明表明较高比例的前列腺癌病例被过度诊断了。

原始出处:

Kvåle R, Myklebust TÅ,et al.Prostate and breast cancer in four Nordic countries: A comparison of incidence and mortality trends across countries and age groups 1975-2013.Int J Cancer. 2017 Aug 10. doi: 10.1002/ijc.30924. [Epub ahead of print]

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1823374, encodeId=31b618233e410, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Feb 11 14:52:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243195, encodeId=b89624319501, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfd1613225, createdName=lsjhyxl, createdTime=Tue Sep 12 11:49:06 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239202, encodeId=c0e1239202b8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Sep 01 06:52:16 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239148, encodeId=692c239148f3, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri Sep 01 00:12:57 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239146, encodeId=39d623914667, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Sep 01 00:11:25 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239127, encodeId=c99223912e0e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Thu Aug 31 23:20:43 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239125, encodeId=e8e623912591, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Aug 31 23:11:07 CST 2017, time=2017-08-31, status=1, ipAttribution=)]
    2017-09-12 lsjhyxl

    学习了谢谢分享

    0

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    2017-09-01 半夏微凉

    学习了谢谢分享

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1823374, encodeId=31b618233e410, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Feb 11 14:52:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243195, encodeId=b89624319501, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfd1613225, createdName=lsjhyxl, createdTime=Tue Sep 12 11:49:06 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239202, encodeId=c0e1239202b8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Sep 01 06:52:16 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239148, encodeId=692c239148f3, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri Sep 01 00:12:57 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239146, encodeId=39d623914667, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Sep 01 00:11:25 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239127, encodeId=c99223912e0e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Thu Aug 31 23:20:43 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239125, encodeId=e8e623912591, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Aug 31 23:11:07 CST 2017, time=2017-08-31, status=1, ipAttribution=)]
    2017-09-01 luominglian113

    学习了.谢谢分享

    0

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    2017-09-01 飛歌

    学习了很有用

    0

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    2017-08-31 䖝二

    学习了

    0

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    2017-08-31 1e1b8538m79(暂无匿称)

    不错的文章.值得一读

    0

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