Diabetes care:2型糖尿病患者BMI与冠心病风险正相关性

2014-10-18 MedSci MedSci原创

一项随访7年的研究显示,2型糖尿病患者的基线BMI水平越高,7年后患冠心病(CHD)的风险越高,且女性2型糖尿病患者的BMI水平和冠心病风险或呈U型相关性。该研究发表于Diabetes care杂志。(Diabetes care   2014 Sep 23 ;)来自美国潘宁顿生物医学研究中心( LA Tianjin Women's and Children's Health Center

一项随访7年的研究显示,2型糖尿病患者的基线BMI水平越高,7年后患冠心病(CHD)的风险越高,且女性2型糖尿病患者的BMI水平和冠心病风险或呈U型相关性。该研究发表于Diabetes care杂志。(Diabetes care   2014 Sep 23 ;)

来自美国潘宁顿生物医学研究中心( LA Tianjin Women's and Children's Health Center)Nan Li博士及其同事在年龄为30-95岁间的10955例男性和19479例女性2型糖尿病患者中,分析BMI与冠心病风险的关联。

在平均7.3年的随访时间里,共有7414例2型糖尿病者患上冠心病。根据基线BMI水平将所有患者分为5组(18.5-24.9, 25-29.9, 30-34.9, 35-39.9 和 ≥40 kg/m2)。经多因素校正后,男性患者中5个不同BMI组的冠心病风险比分别为1.00,、1.14 (95% CI, 1.00-1.29)、1.27 (95% CI, 1.12-1.45)、1.54 (95% CI, 1.34-1.78)和1.42 (95% CI, 1.23-1.64);女性患者中5个不同BMI组的冠心病风险比分别是1.00、0.95 (95% CI, 0.85-1.07)、0.95 (95% CI, 0.84-1.06)、1.06 (95% CI, 0.94-1.2)和1.09 (95% CI, 1.00-1.22)。

采用BMI均数或最后一次随访的BMI值并不影响男性患者BMI与冠心病风险之间的正相关性,但采用最后一次随访的BMI值,可使女性患者BMI与冠心病风险的正相关性变为U型相关性。

原始出处:
Li N, Katzmarzyk PT, Horswell R, Zhang Y, Li W, Zhao W, Wang Y, Johnson J, Hu G.BMI and Coronary Heart Disease Risk Among Low-Income and Underinsured Diabetic Patients.Diabetes Care. 2014 Sep 23. pii: DC_141091.

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    2015-04-11 x35042875

    控制好糖尿病可能提高肝硬化患者的预后。

    0

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    2014-12-15 zutt
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