JAHA:HFpEF与HFREF患者住院期间肾功能恶化的预测和预后价值!

2018-03-13 xing.T MedSci原创

由此可见,在急性心力衰竭患者中,WRF是HFpEF和HFrEF患者不良住院事件和随访不良结局的独立预测因素。

肾功能恶化(WRF)与心力衰竭患者的不良预后有关。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员调查了射血分数(EF)正常(HFpEF)与射血分数降低(HFrEF)的心衰患者住院期间WRF的预测和预后价值。

该研究共招募了5625例患者。WRF的定义是肌酐的绝对增长≥0.3mg/dL。瞬态WRF定义为出院时肌酐恢复,而肌酐水平未恢复表明为持续的WRF。HFpEF和HFrEF分别被定义为左室射血分数≥50%和≤40%。

在总人群中,WRF发生于3101例患者(55.1%)中。在心衰亚组中,WRF在HFrEF患者中发生更频繁(57% vs. 51.3%;P<0.001)。在两种心衰亚组中,WRF患病率随着肌酐清除率下降而增加。在WRF的各个预测因素中,慢性肾功能衰竭是最强的预测因素。WRF是不良住院结局(HFrEF:比值比为2.75;95%可信区间为1.50–5.02;P = 0.001;EFpHF:比值比为9.48;95%可信区间为1.19–75.89;P = 0.034)和1年死亡率(HFrEF:风险比为1.41;95%可信区间为1.12–1.78;P = 0.004和EFpHF:风险比为1.72;95%可信区间为1.23–2.42;P=0.002)的独立预测因子。短暂的WRF是1年死亡率的危险因素,而持续的WRF与瞬间WRF相比没有额外的风险。

由此可见,在急性心力衰竭患者中,WRF是HFpEF和HFrEF患者不良住院事件和随访不良结局的独立预测因素。

原始出处:

Jeehoon Kang,et al. Predictors and Prognostic Value of Worsening Renal Function During Admission in HFpEF Versus HFrEF: Data From the KorAHF (Korean Acute Heart Failure) Registry, JAHA.2018. https://doi.org/10.1161/JAHA.117.007910

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    2018-07-08 yese
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    2018-08-11 feather89
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    2018-03-15 zhaohui6731
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    2018-03-15 bettycmoon
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JAMA:收缩压较低可预测HFpEF预后不良

近日,JAMA杂志发表的一项最新观察性研究结果提示,对于HFpEF住院患者而言,出院时SBP低于120 mm Hg或是低于130 mm Hg与不良结局(全因死亡及再住院等)具有相关性。

JAHA:射血分数正常和减少的心力衰竭患者的生物标志物有区别吗?

由此可见,在HFpEF患者中,可以明显观察到炎症和血管生成介导的相互作用,而HFrEF患者中观察到的主要为心脏牵张介导的相互作用。重塑标志物骨桥蛋白与血管生成标记物神经纤毛蛋白可以预测HFpEF患者的结局,而不能预测HFrEF患者的结局。

Int J Cardiol:他汀类药物对无缺血性心脏病的射血分数正常的心衰患者的疗效分析!

由此可见,他汀治疗与HFpEF患者,特别是那些没有IHD的患者的预后相关。

Circulation:运动状态下的超声心动图在HFpEF诊断中的作用

目前提出的基于静息状态下数据的HFpEF诊断指南并不敏感。加入运动状态下E/e’的数据可以提高灵敏度和阴性预测值,但特异性有所下降,提示运动超声心动图检查可帮助排除HFpEF。这些结果对当前单纯基于静息状态下数据的HFpEF排除方法提出了质疑,加强使用运动状态下的有创和无创血流动力学评估可以明确地证实或排除HFpEF的诊断。

JAHA:胸腺肽β4在射血分数正常的心力衰竭患者中升高!

由此可见,女性HFpEF患者血浆中TB4水平升高,并且可以提供预后信息。因为在心肌损伤的动物实验中TB4能保持EF,因此,女性心脏病患者中内源性循环TB4与X染色体生物学和分化结局值得进一步研究。

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