Stroke:自主神经功能障碍可预测急性缺血性卒中的临床结局!

2017-12-05 xing.T MedSci原创

Ewing试验测得的自主神经功能障碍可以预测急性缺血性卒中患者不良功能结局。

中枢自主神经功能紊乱增加卒中发病率和死亡率。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在评估卒中后自主神经功能障碍能否预测患者临床结局。

在这项前瞻性观察研究中,研究人员评估了采用Ewing试验在症状发作后7天内评估了缺血性卒中患者的自主神经功能。根据自主神经功能紊乱的程度,研究人员将患者分为显著(明确的,严重的或非典型的)或轻微的(正常或早期)自主神经功能缺损组,并将损伤与3个月的改良Rankin量表评分相结合:(较好的结局:改良Rankin量表评分为0-2;不良结局:改良Rankin量表评分为3-6)。

入组的150例患者,平均年龄为66.4±9.9岁,男性为70.7%,其中36例(24.0%)患者为轻度自主神经功能障碍,114例(76.0%)患者为显著自主神经功能障碍。在3个月内,32.5%的显著组患者的功能结局较差,而轻微组患者较差功能结局比例为13.9%(P=0.031)。急性缺血性卒中后自主神经功能障碍程度与3个月不良功能结局的粗略比值比为2.979(95%可信区间为1.071-8.284; P=0.036)。对混杂因素进行校正后,单变量分析(包括性别和入院时美国国立卫生研究院卒中量表评分)确定了2个功能结局亚组之间具有统计学意义,自主神经功能障碍程度仍然独立地预测不利结局,其比值比为3.263(95%可信区间为1.141-9.335; P=0.027)。

由此可见,Ewing试验测得的自主神经功能障碍可以预测急性缺血性卒中患者不良功能结局。

原始出处:

Li Xiong,et al. Autonomic Dysfunction Predicts Clinical Outcomes After Acute Ischemic Stroke A Prospective Observational Study.Stroke.2017.https://doi.org/10.1161/STROKEAHA.117.019312

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    2017-12-10 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

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  8. 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  9. 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    2017-12-05 changjiu

    学习一下谢谢

    0

  10. 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    2017-12-05 方舒

    学习

    0