Sci Rep：磁性介孔硅酸钙/壳聚糖多孔支架具有促进骨生成和增强协同光热疗对抗骨肉瘤的能力

2018-05-18 MedSci MedSci原创

开发多功能生物材料来修复去除肿瘤后的骨缺损并抑制肿瘤复发仍然是临床所面临的巨大挑战。本研究中个，研究人员展示了一种由M型铁氧体颗粒（SrFe12O19）、介孔硅酸钙（CaSiO3）和壳聚糖（CS）制成的创新型多功能磁性介孔钙硅酸盐/壳聚糖（MCSC）多孔支架，具有强大的抗肿瘤和骨再生性能。 CaSiO3微球中的介孔有助于药物递送，并且SrFe12O19颗粒改善了光热疗法（PTT）的转化效率。

开发多功能生物材料来修复去除肿瘤后的骨缺损并抑制肿瘤复发仍然是临床所面临的巨大挑战。本研究中个，研究人员展示了一种由M型铁氧体颗粒（SrFe12O19）、介孔硅酸钙（CaSiO3）和壳聚糖（CS）制成的创新型多功能磁性介孔钙硅酸盐/壳聚糖（MCSC）多孔支架，具有强大的抗肿瘤和骨再生性能。

CaSiO3微球中的介孔有助于药物递送，并且SrFe12O19颗粒改善了光热疗法（PTT）的转化效率。在NIR激光照射下，阿霉素（DOX）可从MCSC/DOX支架中迅速释放出来。体外和体内试验表明，通过DOX药物释放和高温消融的协同作用，MCSC支架具有优异的抗肿瘤功效。此外，BMP-2/Smad/Runx2通路参与了MCSC支架促进人骨髓基质细胞（hBMSCs）的增殖和成骨分化。

总而言之，MCSC支架具有促进骨生成和增强协同光热疗对抗骨肉瘤的能力，这表明MCSC支架可能在骨肿瘤相关缺陷修复中具有巨大的应用潜力。

原始出处：

Yang F, Lu J, et al., Magnetic Mesoporous Calcium Sillicate/Chitosan Porous Scaffolds for Enhanced Bone Regeneration and Photothermal-Chemotherapy of Osteosarcoma. Sci Rep. 2018 May 9;8(1):7345. doi: 10.1038/s41598-018-25595-2.

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2018-12-01 minlingfeng

#光热疗#

43 0
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2018-12-12 szhvet

#硅酸钙#

27 0
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2018-07-31 luckyshitiancai_42705692

#介孔#

44 0
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2019-02-01 zhaohui6742

#热疗#

50 0
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2018-05-25 txqjm

谢谢了.学习

71 0
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2018-05-23 121ff658m46暂无昵称

骨水泥的区别

68 0
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2018-05-20 dlwang_26703132

#壳聚糖#

32 0
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2018-05-19 chunjianf

学习了.谢谢分享

64 0
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2018-05-19 131****1460

学习了受益匪浅

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Sci Rep：磁性介孔硅酸钙/壳聚糖多孔支架具有促进骨生成和增强协同光热疗对抗骨肉瘤的能力

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