Saudi J Anaesth：右旋美托咪啶滴鼻可减少七氟醚麻醉后躁动的发生率

2017-06-09 MedSci MedSci原创

七氟醚麻醉后躁动（EA）在儿童全身麻醉苏醒期很常见，可能会导致术后并发症。该研究评估了右旋美托咪啶滴鼻在减少EA发生率和严重程度方面的安全性和有效性。该研究是前瞻性随机双盲对照试验，共纳入了86名计划在七氟醚全麻下进行扁桃体切除术和/或腺样体切除术的患者，并随机分为两组。全麻诱导后D组接受1ug/kg剂量的右旋美托咪啶滴鼻，C组用0.9%生理盐水滴鼻。在六个时间点（拔管后、离开手术室时、达

七氟醚麻醉后躁动（EA）在儿童全身麻醉苏醒期很常见，可能会导致术后并发症。该研究评估了右旋美托咪啶滴鼻在减少EA发生率和严重程度方面的安全性和有效性。

该研究是前瞻性随机双盲对照试验，共纳入了86名计划在七氟醚全麻下进行扁桃体切除术和/或腺样体切除术的患者，并随机分为两组。全麻诱导后D组接受1ug/kg剂量的右旋美托咪啶滴鼻，C组用0.9%生理盐水滴鼻。在六个时间点（拔管后、离开手术室时、达到麻醉后监护病房[PACU]时，到达PACU后10、20、30min）采用四点躁动评分和脸部，腿部，活动，哭泣和舒适度（FLACC）量表进行疼痛评估。除了副作用外，还记录拔管、出血和放电时间。

D组和C组的EA发生率具有显著的统计学差异（分别为6.98%和58%，P=0.001）。在所有六个时间点，D组四点躁动评分的中位数和FLACC疼痛评分的中位数明显比C组低，P＜0.05。两组的拔管，出血和放电时间相当，没有受试者报告任何不良反应。

本研究表明进行儿童扁桃体切除术和/或腺样体切除术时，麻醉诱导后给予1ug/kg右旋美托咪啶滴鼻可以减少七氟醚麻醉后EA的发生率和严重程度，无副作用且剖面恢复光滑。

原始出处：

Ahmed Mostafa Abd El-Hamid, Hany Mahmoud Yassin. Effect of intranasal dexmedetomidine on emergence agitation after sevoflurane anesthesia in children undergoing tonsillectomy and/or adenoidectomy. Saudi J Anaesth. 2017 Apr-Jun; 11(2): 137–143.doi: 10.4103/1658-354X.203020
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2017-12-29 一叶知秋

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2018-02-10 AspirantSuo

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2017-11-09 xiangyuzhou971

#EST#

41 0
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2017-06-11 ff4027

不错好东西

54 0
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2017-06-10 linagood

#七氟醚#

33 0
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2017-06-09 Y—xianghai

学习了新知识

40 0
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2017-06-09 执着追梦

学习，谢谢分享

51 0
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channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jun 09 08:08:34 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
2017-06-09 158****8818

新的研究成果，值得借鉴

46 0
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channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Jun 09 08:08:34 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
2017-06-09 1ddf0692m34(暂无匿称)

学习了，涨知识

55 0
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2017-06-09 明月清辉

谢谢分享，学习了

23 0