第75届ADA年会亮点回顾

2015-06-30 磨砂 cmt

adminms

北京妇产医院妇幼保健院医生/ 主任医师

第75届美国糖尿病学会(ADA2015)科学年会，6月5-9日在波士顿盛大召开，公布了两个大型2型糖尿病药物心血管安全性试验——TECOS和ELIXA的研究结果。

糖尿病领域基础研究、临床研究和转化医学的最新亮点包括：

1、TECOS研究：西格列汀不增加糖尿病高危患者心衰风险

2、ELIXA研究：利西拉来不增加心血管事件

3、仿生胰腺：不同方法的进展

4、减重和肌肉保持：5年WhyWAIT项目成功完成

5、4种糖尿病酮酸中毒发作早死风险增加2倍

6、1型糖尿病常见阻塞性呼吸睡眠暂停综合征

7、Meta分析显示，磺脲类药物未增加死亡风险

TECOS研究：西格列汀不增加糖尿病高危患者心衰风险

TECOS研究是一项有关伴心血管疾病的2型糖尿病患者在接受常规治疗基础上，加用二肽基肽酶-4(DPP-4)抑制剂西格列汀对此类患者心血管事件影响的随机、双盲、安慰剂对照试验。其结果显示，西格列汀不增加此类患者达到心血管死亡、非致死性心梗、非致死性卒中或不稳定心绞痛住院的复合终点事件风险，也不增加心衰住院或其他不良反应事件的风险。

EricPeterson，来自杜克临床研究中心，对TECOS研究结果进一步解释说，TECOS研究规模够大、随访时间够长且均为高危人群，能充分证明西格列汀对心衰的影响。

ELIXA研究：利西拉来不增加心血管事件

胰高血糖素样肽(GLP)-1受体激动剂lixisenatide，未在纳入6000例患急性冠脉综合征的糖尿病高危患者的ELIXA研究众获益，与安慰剂组相比，lixisenatide也未增加心血管死亡、非致命性心肌梗死、非致命性卒中或不稳定心绞痛住院率。

MarcPfeffer教授，来自波士顿Brigham妇产医院，ELIXA首席研究员，说到，ELIXA研究中lixisenatide的影响为中性，这对医师和患者都是一个安慰。

仿生胰腺不同途径的进展

会上有几个研究团队报告了仿生胰腺系统的发展，进步是循序渐进稳步发展的，但仍有一些挑战：阻止低血糖事件的发生，通过延迟皮下注射胰岛素吸收，系统已经大大降低了餐后血糖峰值，但不是完全消除。同时，会上有科学家强调任何器械进入商业领域都需要一定的年限，仿生胰腺可能会在2018年上市。仿生胰腺并不能完全治愈1型糖尿病，它只是在发现细胞治愈之前的一座桥梁。

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2015-08-05 hlycom3356

这些亮点挺有趣的

88 0
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2015-08-05 hlycom3356

不过都对医学领域做出了卓越贡献

162 0
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2015-08-05 hlycom3356

希望他们都能够继续努力吧

98 0
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2015-08-05 hlycom3356

未来我们的医学将更好

88 0
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2015-07-29 1dd95637m50(暂无匿称)

看看

115 0
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2015-07-29 1dd95637m50(暂无匿称)

了解学科最新进展

74 0
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2015-07-29 1dd95637m50(暂无匿称)

很开心在这里能学到许多东西

71 0
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2015-07-04 huaxipanxing

看看

54 0
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2015-07-02 般若傻瓜

#ADA#

24 0
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2015-06-30 owlhealth

好研究我喜欢

45 0

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