Oral Oncol:饮绿茶可降低男性人群的口腔癌风险

2014-01-25 PCMC dxy

研究要点1、绿茶摄入与男性口腔癌风险减少相关,而女性人群则未见此效应,吸烟越厉害的男性效果越好;无迹象表明红茶消费与口腔癌风险减少相关。2、日前,中国上海交通大学头颈癌研究中心的Zhi-Yuan Zhang博士等研究者发表于Oral Oncology的一项研究显示,绿茶消费或可减少男性人群特别是男性重度吸烟人群的口腔癌风险。这项基于住院人群的多中心病例对照研究旨在评估中国人群茶消费与口腔癌风险之间

研究要点

1、绿茶摄入与男性口腔癌风险减少相关,而女性人群则未见此效应,吸烟越厉害的男性效果越好;
无迹象表明红茶消费与口腔癌风险减少相关。
2、日前,中国上海交通大学头颈癌研究中心的Zhi-Yuan Zhang博士等研究者发表于Oral Oncology的一项研究显示,绿茶消费或可减少男性人群特别是男性重度吸烟人群的口腔癌风险。

这项基于住院人群的多中心病例对照研究旨在评估中国人群茶消费与口腔癌风险之间的相关性。红茶和绿茶分别进行分析。研究分别纳入了723例和857例对照者。研究者利用多种无条件逻辑回归模型来计算比值比(ORs)及茶消费人群95%置信区间的口腔癌风险。 【原文下载】

结果显示,与每天消费绿茶<4g的受试者相比,每天消费绿茶水平不小于8 g的男性和女性受试者的Ors分别为0.72和0.93。与红茶消费每天不足2克的人群相比,每天消费量不小于6g的男性人群Ors为0.97,女性人群为0.91。绿茶摄入与男性口腔癌风险减少相关,而女性人群则未见此效应,吸烟越厉害的男性效果越好。无迹象表明红茶消费与口腔癌风险减少相关。

研究者得出如下结论:此研究的结果提示绿茶消费或可减少男性人群特别是男性重度吸烟人群的口腔癌风险。

研究背景

口腔癌包括舌癌、颊黏膜癌、牙龈癌、硬腭和口底癌,是全世界发病率排在第8位的癌症。据报道,在中国, 2008年口腔癌的发生率为每10万人中发生3.29例,死亡率为每10万人死亡1.49例。

在全球许多地方,口腔癌都是一种越来越重要的疾病,主要原因是其生存率低,且严重影响生活质量,特别是晚期癌症。因此,初级预防有着重要意义。饮茶因其潜在的癌症预防功能而成为人类多年以来关注的焦点。实验室研究的证据强力表明茶及其成分对肿瘤生成的抑制作用。

其机制包括信号转导和代谢途径的调控,进而导致细胞凋亡的增强,细胞增殖的抑制及血管生成的抑制。

然而,有关这一问题的流行病学研究非常有限,其结果也不一致。中国人群有悠久的饮茶传统。饮茶之风蔚成大观,许多人有每日饮茶的习惯。市面上有多种茶业出售,红茶和绿茶是其中的两大茶种。因此,开展一项关于饮茶习惯与口腔癌风险的大型研究非常便利。该项研究中,研究者分析了饮茶与口腔癌发生风险之间的相关性,并从多中心病例对照研究的数据中分析中国人群口腔癌的风险因素。

原文出处:
Fu JY, Gao J, Zhang ZY, Zheng JW, Luo JF, Zhong LP, Xiang YB.Tea consumption and the risk of oral cancer incidence: a case-control study from China.Oral Oncol. 2013 Sep;49(9):918-22. doi: 10.1016/j.oraloncology.2013.05.002. 【原文下载】

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    2014-12-19 小几洁
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    2014-06-21 minlingfeng
  3. [GetPortalCommentsPageByObjectIdResponse(id=2020140, encodeId=cf902020140b1, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Fri Dec 19 13:32:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864502, encodeId=42461864502dd, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 21 22:32:00 CST 2014, time=2014-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402269, encodeId=52b7140226943, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Mon Jan 27 02:32:00 CST 2014, time=2014-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061417, encodeId=3fa5206141e8e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Aug 30 13:32:00 CST 2014, time=2014-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7101, encodeId=8bd4e101bb, content=不知道有没有医生想做一下绿茶与肿瘤的meta分析,可能会得出很有价值的信息。另外,在研究中,也可以关注这些细节, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci特约评论员, createdTime=Sat Jan 25 21:48:00 CST 2014, time=2014-01-25, status=1, ipAttribution=)]
    2014-01-27 hbwxf
  4. [GetPortalCommentsPageByObjectIdResponse(id=2020140, encodeId=cf902020140b1, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Fri Dec 19 13:32:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864502, encodeId=42461864502dd, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 21 22:32:00 CST 2014, time=2014-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402269, encodeId=52b7140226943, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Mon Jan 27 02:32:00 CST 2014, time=2014-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061417, encodeId=3fa5206141e8e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Aug 30 13:32:00 CST 2014, time=2014-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7101, encodeId=8bd4e101bb, content=不知道有没有医生想做一下绿茶与肿瘤的meta分析,可能会得出很有价值的信息。另外,在研究中,也可以关注这些细节, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci特约评论员, createdTime=Sat Jan 25 21:48:00 CST 2014, time=2014-01-25, status=1, ipAttribution=)]
    2014-08-30 sjq027
  5. [GetPortalCommentsPageByObjectIdResponse(id=2020140, encodeId=cf902020140b1, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Fri Dec 19 13:32:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864502, encodeId=42461864502dd, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Jun 21 22:32:00 CST 2014, time=2014-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402269, encodeId=52b7140226943, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Mon Jan 27 02:32:00 CST 2014, time=2014-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061417, encodeId=3fa5206141e8e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Aug 30 13:32:00 CST 2014, time=2014-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7101, encodeId=8bd4e101bb, content=不知道有没有医生想做一下绿茶与肿瘤的meta分析,可能会得出很有价值的信息。另外,在研究中,也可以关注这些细节, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci特约评论员, createdTime=Sat Jan 25 21:48:00 CST 2014, time=2014-01-25, status=1, ipAttribution=)]
    2014-01-25 MedSci特约评论员

    不知道有没有医生想做一下绿茶与肿瘤的meta分析,可能会得出很有价值的信息。另外,在研究中,也可以关注这些细节

    0

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江苏省人民医院心内科教授王连生主任医师所带领的科研小组近日发布的临床研究表明:长期饮用绿茶可预防冠心病,不支持喝红茶可预防冠心病。相关研究成果先后刊发在日本循环杂志和美国临床营养杂志上。 据介绍,茶起源于中国,作为中国人饮食结构中不可或缺的元素,绿茶常被誉为“国饮”。但长期以来,关于绿茶效用的说法不一而足。 王连生教授自2008年起开始通过对照研究了520名首次

饮用大量绿茶或可以抑制前列腺癌

  一项新的研究显示:饮用大量绿茶可以通过减少炎症,刺激细胞凋亡而抑制前列腺癌的发展。该研究由加利福利亚大学David Geffen医学院M.Henning博士发表在美国癌症研究学会(AACR)第11届癌症预防会议上。   M.Henning博士说,饮用绿茶的前列腺癌患者,与不饮用绿茶的患者比,前列腺组织的炎症较轻,这与癌生长和其他变化有关。   “我们可以表明绿茶多酚(抗氧化剂)到达前列腺组

Stroke:多饮绿茶和咖啡降低卒中风险

  日本一项大规模队列研究显示,多饮绿茶和咖啡与一般人群卒中风险呈负相关。论文2013年3月14日在线发表于《卒中》(Stroke)杂志。   研究纳入82369名受试者(年龄45~74岁,无心血管疾病及癌症),平均随访13年。结果为,与几乎不饮绿茶者相比,每日饮用绿茶分别为2~3杯或≥4杯者发生卒中的风险比(HR)为0.86和0.80;与几乎不饮咖啡者相比,饮咖啡3~6次/周、1次/日或≥2次

星岛日报:饮用绿茶或可预防糖尿病

据澳洲《星岛日报》报道,候伯特(Hobart)Menzies研究中心华裔博士生利用老鼠实验发现饮用绿茶的可预防糖尿病。 吴海伦(Helena Ng,音译)指出,被喂以不良饮食的实验老鼠通常会患上早期糖尿病,但同时饮用绿茶的却无发病。她表示,证实此大受欢迎的亚洲饮品于人类身上能同样起到预防疾病作用之前,她需要找出令人大量饮用的方法。 “大多数本地人不喜欢绿茶”,吴