PeerJ:下丘脑和齿状小脑核中央核心深部脑刺激期间的听力评估

2017-10-20 AlexYang MedSci原创

之前,有研究表明在动物研究中,听觉结构的深部脑刺激(DBS)能够减少类似耳鸣的症状。然而,是否在听觉相关的网络回路中,DBS的介入对听力造成损伤仍旧是个亟待解决的问题。最近,有研究人员在高频刺激(HFS)和低频刺激(LFS)小鼠的下丘脑(CIC,n=5)或者齿状小脑核(DCBN,n=5)中央核中测量了听力脑干响应(ABR)。另外,除了利用ABR可测量听力阈值,还可以从ABR中获取延迟和振幅的相对测

之前,有研究表明在动物研究中,听觉结构的深部脑刺激(DBS)能够减少类似耳鸣的症状。然而,是否在听觉相关的网络回路中,DBS的介入对听力造成损伤仍旧是个亟待解决的问题。

最近,有研究人员在高频刺激(HFS)和低频刺激(LFS)小鼠的下丘脑(CIC,n=5)或者齿状小脑核(DCBN,n=5)中央核中测量了听力脑干响应(ABR)。另外,除了利用ABR可测量听力阈值,还可以从ABR中获取延迟和振幅的相对测量数据。研究人员还在研究中测量了刺激结束后和LFS以及HFS期间的ABR阈值、峰间延迟(I-III, III-V, I-V)和V/I 振幅比。研究结果表明,在CIC组和CNBN组中,并没有在所有测量结果中发现显著的差异。最后,研究人员指出,DBS在CIC和CNBN组中对听力并没有负面影响。这些发现表明了DBS并没有妨碍听觉回路的生理过程。

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    2017-12-19 sjzlzc007
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    2017-12-14 feather89
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    2018-08-03 fengxx
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    2017-10-22 ysjykql
  5. [GetPortalCommentsPageByObjectIdResponse(id=1786925, encodeId=78961e8692524, content=<a href='/topic/show?id=3bd213998ca' target=_blank style='color:#2F92EE;'>#peer#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13998, encryptionId=3bd213998ca, topicName=peer)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Tue Dec 19 03:08:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726814, encodeId=9ca01e2681458, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Dec 14 22:08:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722672, encodeId=1a7b1e226726a, content=<a href='/topic/show?id=75d4220e8ae' target=_blank style='color:#2F92EE;'>#中央核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22078, encryptionId=75d4220e8ae, topicName=中央核)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8e933296487, createdName=fengxx, createdTime=Fri Aug 03 22:08:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306123, encodeId=a6ea1306123c2, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435938, encodeId=d2b21435938e5, content=<a href='/topic/show?id=c8ba20119d1' target=_blank style='color:#2F92EE;'>#下丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20119, encryptionId=c8ba20119d1, topicName=下丘脑)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457659, encodeId=9687145e65948, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558294, encodeId=17c1155829471, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564303, encodeId=08b415643031f, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1786925, encodeId=78961e8692524, content=<a href='/topic/show?id=3bd213998ca' target=_blank style='color:#2F92EE;'>#peer#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13998, encryptionId=3bd213998ca, topicName=peer)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Tue Dec 19 03:08:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726814, encodeId=9ca01e2681458, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Dec 14 22:08:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722672, encodeId=1a7b1e226726a, content=<a href='/topic/show?id=75d4220e8ae' target=_blank style='color:#2F92EE;'>#中央核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22078, encryptionId=75d4220e8ae, topicName=中央核)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8e933296487, createdName=fengxx, createdTime=Fri Aug 03 22:08:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306123, encodeId=a6ea1306123c2, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435938, encodeId=d2b21435938e5, content=<a href='/topic/show?id=c8ba20119d1' target=_blank style='color:#2F92EE;'>#下丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20119, encryptionId=c8ba20119d1, topicName=下丘脑)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457659, encodeId=9687145e65948, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558294, encodeId=17c1155829471, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564303, encodeId=08b415643031f, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Sun Oct 22 12:08:00 CST 2017, time=2017-10-22, status=1, ipAttribution=)]
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    2017-10-22 xlwang2696
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