Mol Psychiatry:啥?抗炎药也可以治疗抑郁?

2016-10-20 MedSci MedSci原创

一项系统回顾和荟萃分析的结果表明,抗细胞因子治疗抑郁症是有效的!这表明,这些药物可能对抑郁症和相关疾病有潜在的治疗作用。 剑桥大学的Golam Khandaker博士说:越来越多的证据表明,炎症在抑郁症中起着一定作用;这项系统回顾和荟萃分析也表明,抗炎治疗对抑郁症有益!不过这种抗炎药不是我们平时使用的消炎药如布洛芬,而是某一类新的药物。 为了评估细胞因子在抑郁症的发病机制和治疗中的潜在

一项系统回顾和荟萃分析的结果表明,抗细胞因子治疗抑郁症是有效的!这表明,这些药物可能对抑郁症和相关疾病有潜在的治疗作用。 剑桥大学的Golam Khandaker博士说:越来越多的证据表明,炎症在抑郁症中起着一定作用;这项系统回顾和荟萃分析也表明,抗炎治疗对抑郁症有益!不过这种抗炎药不是我们平时使用的消炎药如布洛芬,而是某一类新的药物。 为了评估细胞因子在抑郁症的发病机制和治疗中的潜在作用,研究人员对20项临床试验进行了系统回顾和荟萃分析。 7项随机对照试验(涉及2370名受访者)进行的荟萃分析结果表明,抗细胞因子治疗有明显的抗抑郁作用(与安慰剂组相比,平均数标准差= 0.4; 95% CI, 0.22-0.59)。 抗肿瘤坏死因子药物是最常用的研究药物,与安慰剂组相比,标准化的平均差异为0.33 (95% CI, 0.06-0.6)。 对2项抗细胞因子治疗的随机临床试验和8项非随机或非对照研究进行单独的荟萃分析,表现出了类似的效果,抗细胞因子治疗对抑郁有小到中等程度的疗效。 阿达木单抗(Humira, AbbVie Inc.)、依那西普(Enbrel, Amgen)、英夫

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    2016-10-20 1e128d2fm65(暂无匿称)

    一药两用,额外好处

    0

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