Circulation:急性心衰患者合并症发生率和预后的十年变化趋势

2020-08-01 QQY MedSci原创

心衰(HF)患者有多种合并症。射血分数保留(HFpEF)和射血分数降低(HFrEF,射血分数<50%)的HF患者的合并症负担和死亡相关风险的时间趋势尚未明确。

心衰(HF)患者有多种合并症。射血分数保留(HFpEF)和射血分数降低(HFrEF,射血分数<50%)的HF患者的合并症负担和死亡相关风险的时间趋势尚未明确。

Pandey等采用分层设计,对2005年-2014年在美国4个地区住院的患者中进行抽样调查。从病历中提取了15种合并症。通过将医院记录与死亡档案相关联,确定入院后1年内的死亡结果。

共5460例住院患者被划分为急性失代偿性HF有可及的射血分数数据(53% 女性,68% 白种人,53% HFrEF,47% HFpEF)。无论男性还是女性,HFpEF患者的合并症平均数均高于HFrEF患者(女性:5.53 vs 4.94;男性:5.20 vs 4.82)。合并症的总体负担随着时间的推移显著增加,无论射血分数如何。


较高的合并症负担与较高的1年死亡率风险显著相关,该相关性在HFrEF患者中更强。此外,随着时间的推移,HFpEF和HFrEF患者每1个合并症的相关死亡风险都明显增加。

综上所述,急性失代偿性HFpEF和HFrEF住院患者的合并症负担及其相关的死亡风险均随着时间的推移而增加。高合并症负担与高死亡风险相关,特别是对于HFrEF患者。

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    2020-08-01 lovetcm

    #真实世界研究#趋势分析,疾病负担分析

    0

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