PAEDIATR PERINAT EP:孕前肥胖与早产相关

2014-07-01 孟小猫 编译 医学论坛网

根据一项发表在《儿科与围产期流行病学》人口基础队列研究显示,肥胖的孕期女性更有可能早产,体重系数(BMI)风险与孕期女性的相关性比较复杂,同时受到种族、胎龄和经产次数相关。本文于6月27日发表于《医景》。 “截至此时,人们依旧认为早产只是一种状况,将其简单定义为婴儿提早出生3周以上的一种状况。”来自加利福尼亚帕洛阿尔托斯坦福大学医学院的儿科教授、本研究的主要作者 Cary Shaw对媒体说道,“

根据一项发表在《儿科与围产期流行病学》人口基础队列研究显示,肥胖的孕期女性更有可能早产,体重系数(BMI)风险与孕期女性的相关性比较复杂,同时受到种族、胎龄和经产次数相关。本文于6月27日发表于《医景》。

“截至此时,人们依旧认为早产只是一种状况,将其简单定义为婴儿提早出生3周以上的一种状况。”来自加利福尼亚帕洛阿尔托斯坦福大学医学院的儿科教授、本研究的主要作者 Cary Shaw对媒体说道,“事实上,却不像看上去的那么简单。早产属于胎龄问题。”

通过使用2007年至2009年加利福尼亚989687单胞胎队列,研究者检查了孕前体重指数与一定范围内自发性早产体重指数、孕龄和种族/族裔。他们排除了孕前糖尿病的女性、妊娠糖尿病的女性、妊娠高血压的女性、先兆子痫的女性以及慢性高血压的女性。

当调整了产妇年龄、学历、身高和产前护理之后,孕前肥胖(体重指数BMI ≥ 30.0 kg/m2)首次怀孕的人群在28周前早产的风险显著增加,但与胎龄关系不大。针对每一个种族/族裔群体,风险最高的情况为早期胎龄和高水平的肥胖。

针对首次怀孕的三类肥胖(BMI ≥ 40.0 kg/m2), 20周至23周内早产的相关风险,非西班牙裔白人为6.29,非西班牙裔黑人为4.34,西班牙裔人群为4.45。

对于二次或多次生育的肥胖女性,在20周至23周内早产的风险高于体重正常的女性,但相关风险低于肥胖的初次生育女性。

除去经产次数或种族差异的因素外,体重过轻(BMI < 18.5 kg/m2)与24周至28周内的早产分娩相关。

这项研究的限制包括来自排除的出生证明和数据。

“理想情况下,作为美国学院的产科与妇科医生,个人建议女性在怀孕前养成一个健康的饮食习惯和运动习惯,”本研究的共同作者斯坦福妇产科副教授、斯坦福Lucile Packard儿童医院产科医生 Lyell 博士对媒体说道。

“肥胖的女性应该考虑符合产科医生的建议并理解本项研究所陈述的风险。”她补充道。

肥胖的附加风险还包括妊娠糖尿病的高发病率、先兆子痫和剖宫产。

尽管已知黑人女性的早产风险,本项研究依旧不能解释种族差异下肥胖对早产的影响。

“这将是一个线索信息,指引着接下来的研究方向。”Shaw博士对媒体说道,“我们相信炎症性反应对早产产生影响,特别是早期胎龄。我们正在解决这个边缘问题。”

原始出处:


Prepregnancy Obesity Linked to Earliest Preterm Births.Medscape.June 27, 2014

Shaw GM1, Wise PH, Mayo J, Carmichael SL, Ley C, Lyell DJ, Shachar BZ, Melsop K, Phibbs CS, Stevenson DK, Parsonnet J, Gould JB; March of Dimes Prematurity Research Center at Stanford University School of Medicine.Maternal prepregnancy body mass index and risk of spontaneous preterm birth.Paediatr Perinat Epidemiol. 2014 Jul;28(4):302-11. doi: 10.1111/ppe.12125. Epub 2014 May 9.

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    2015-05-25 liye789132251
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    2014-08-14 feather89
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    2014-11-10 仁医06
  5. [GetPortalCommentsPageByObjectIdResponse(id=1880146, encodeId=b971188014650, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon May 25 08:49:00 CST 2015, time=2015-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725628, encodeId=13711e256285c, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Aug 14 22:49:00 CST 2014, time=2014-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636902, encodeId=bedc1636902cf, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Mar 15 23:49:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659544, encodeId=1f621659544b1, content=<a href='/topic/show?id=c42845239ef' target=_blank style='color:#2F92EE;'>#孕前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45239, encryptionId=c42845239ef, topicName=孕前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Mon Nov 10 09:49:00 CST 2014, time=2014-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10333, encodeId=26ed103336c, content=孕前及孕期的体重控制真的非常重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42e3105098, createdName=sunxiaofei4457, createdTime=Tue Jul 08 09:44:00 CST 2014, time=2014-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10290, encodeId=f5a310290a6, content=很好!学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/1oeP10R7SWYfgg6QBRpjgiaiaCLyGAnK0VXpibCJzyljhCjico0Gmmf9UUeGfc5ERibMX2PM9xbIOZqMjBjcLhfX4tA/132, createdBy=7340105168, createdName=zhangjunxiao, createdTime=Sun Jul 06 18:08:00 CST 2014, time=2014-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489818, encodeId=3489148981885, content=<a href='/topic/show?id=bcd5204ea9' target=_blank style='color:#2F92EE;'>#AED#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2047, encryptionId=bcd5204ea9, topicName=AED)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0108610571, createdName=makuansheng, createdTime=Thu Jul 03 06:49:00 CST 2014, time=2014-07-03, status=1, ipAttribution=)]
    2014-07-08 sunxiaofei4457

    孕前及孕期的体重控制真的非常重要!

    0

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    2014-07-06 zhangjunxiao

    很好!学习了。

    0

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    2014-07-03 makuansheng

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