Med Hypotheses：猪鞭虫或可用于治疗自闭症谱系障碍

　　自闭症和自闭症谱系障碍（ASDs）是异质的严重神经发育障碍性疾病。主要核心症状有：社交和沟通障碍、兴趣有限、语言和非语言行为重复刻板。ASDs与多个生化过程相关：氧化应激、内质网应激、甲基化能力下降、谷胱甘肽合成受限、线粒体功能障碍、肠道微生态失调、有毒金属负荷增加、免疫失调。尽管还没有确定的标准治疗方法，目前已有的ASDs治疗方法可以分为：行为、营养和药物治疗方法。当前的治疗药物不能改善ASD核心症状且可能有明显的不良反应，药物治疗主要是姑息治疗，仅有时在缓解特定的自闭症行为方面有效。蠕虫治疗作为抗炎药显示了应用潜力。蠕虫治疗可以治疗多种人类疾病，如炎症性肠病、哮喘、多发性硬化和自身免疫型糖尿病。猪鞭虫（TSO）显示出较强的免疫调节特性。作者假设TSO在处理ASD免疫调节异常方面可能会有所帮助。TSO可能成为ASD管理中一项新的治疗选择。

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Possible use of Trichuris suis ova in autism spectrum disorders therapy.
Abstract
Autism and autism spectrum disorders (ASDs) are heterogeneous, severe neurodevelopmental pathologies. The main core symptoms are: dysfunctions in social interactions and communication skills, restricted interests, repetitive and stereotypic verbal and non-verbal behaviors. Several biochemical processes are associated with ASDs: oxidative stress; endoplasmic reticulum stress; decreased methylation capacity; limited production of glutathione; mitochondrial dysfunction; intestinal dysbiosis; increased toxic metal burden; immune dysregulation. Current available treatments for ASDs can be divided into behavioral, nutritional and medical approaches, although no defined standard approach exists. Current drugs fail to benefit the ASD core symptoms and can have marked adverse effects, are mainly palliative and only sometimes efficacy in attenuating specific autistic behaviors. Helminthic therapy shows potential for application as anti-inflammatory agent. Several human diseases can be treated by helminths (i.e. inflammatory bowel disease, asthma, multiple sclerosis and autoimmune diabetes). Trichuris suis ova (TSO) show strong immunomodulatory properties. Authors hypothesize that TSO could be useful in addressing ASD immune dysregulations. TSO could be a novel therapeutic option for ASD management.