JCEM:1型糖尿病年轻人睡眠特征与血糖调节的关系

2021-11-02 MedSci原创 MedSci原创

临床医生可以通过优化睡眠和夜间维持正常血糖范围来解决睡眠-血糖关系的相互性质。睡眠习惯是糖尿病治疗中可改变的个人目标。

睡眠时间在全球人群中正在不断变短,大多数18-30岁的年轻人没有达到每晚7-9小时的睡眠时间。睡眠时间较短和睡眠中断与1型糖尿病(T1D)患者血糖调节受损有关。然而,睡眠和血糖变异性之间的关联和机制尚未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在明确客观睡眠-觉醒特征和血糖变异指数之间同一个体内和不同个体间的关联程度。

研究人员采用多层次模型(MLM)分析了42名患有T1D的年轻人在其自然家庭环境中超过7天的并发睡眠和血糖模式。该研究纳入了T1D患者(平均年龄为22.2±3.0岁,HbA1C为7.2%,32.6%为男性)至少6个月没有其它医学或主要精神疾病合并症的年轻成人。该研究的主要观察指标为通过连续血糖监测仪(CGM)获得血糖变异指数,并通过腕表记录了睡眠-觉醒特征。

较低的睡眠效率可预测个体内较高的血糖变异性(范围内时间较短β=0.011,高血糖症的时间较长β=-0.011)。入睡后醒来时间越长,睡眠中断越多,个体间的血糖变异性越高(β=0.28-0.31)。较高的血糖变异性预示着个体睡眠较差(入睡时间延迟、清醒时间、睡眠中期和较低的睡眠效率),而较高的血糖变异性与较差的睡眠和个体间更多睡眠中断相关(较低的睡眠效率、睡眠后醒来时间较长以及更高的睡眠碎片指数)。

由此可见,临床医生可以通过优化睡眠和夜间维持正常血糖范围来解决睡眠-血糖关系的相互性质。睡眠习惯是糖尿病治疗中可改变的个人目标。

原始出处:

Stephanie Griggs.et al.Variations in Sleep Characteristics and Glucose Regulation in Young Adults with Type 1 Diabetes.JCEM.2021.https://doi.org/10.1210/clinem/dgab771

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    2022-06-01 achengzhao
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    2022-03-20 仁者大医
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    2021-11-03 ms8000000945331327

    学习学习

    0

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    2021-11-03 ms1000002136354097

    睡眠影响血糖

    0

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    2021-11-03 查查佳佳

    动脉高压 (PAH) 是一种罕见但重要的限制生命的疾病

    0

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    2021-11-02 jumpboat

    很好

    0

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    2021-11-02 ms1000001127428570

    学习

    0

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