Nutrition:警示!“炎症性饮食”或增加结直肠癌风险

2017-07-14 吴刚 环球医学

慢性炎症可造成癌症。饮食通过改变炎症生物标志物的循环水平而在调节慢性炎症中起到重要作用。2017年6月,发表在《Nutrition》的一项在加拿大纽芬兰进行的基于人群的病例对照研究调查了炎症性饮食和结直肠癌风险之间的相关性。



慢性炎症可造成癌症。饮食通过改变炎症生物标志物的循环水平而在调节慢性炎症中起到重要作用。2017年6月,发表在《Nutrition》的一项在加拿大纽芬兰进行的基于人群的病例对照研究调查了炎症性饮食和结直肠癌风险之间的相关性。

目的:慢性炎症可造成癌症。饮食通过改变炎症生物标志物的循环水平而在调节慢性炎症中起到重要作用。单一食物或营养素对癌症的影响尚不确定。本研究旨在确定饮食的促炎症潜力与结直肠癌(CRC)风险之间的相关性。

研究方法:总共纳入了547例CRC病例(来自于纽芬兰结直肠癌注册)和686例来自于普通人群的对照。社会人口学、用药史、生活方式和169条目的食物频率调查问卷等数据从两组中回顾性收集。研究者计算了饮食炎症指数(DII)评分,并用作分类和连续变量进行分析。调整了潜在混杂因素后的多变量逻辑回归用于评估比值比。使用每个四分位数的中位值进行趋势的线性检验。

结果:调整后总能量的平均DII评分为-0.81(范围:-5.19~6.93)。病例(-0.73±1.5)比对照(-0.89±1.6)的DII评分稍高(P=0.04)。调整潜在混杂因素后,无论使用DII作为连续变量(OR,1.10;95% CI,1.01~1.20),还是作为分类变量(OR,1.65;95% CI,1.13~2.42),DII评分和CRC风险之间均具有统计学显着的相关性(P=0.02)。

结论:结果表明,纽芬兰人群中,促炎症饮食与CRC风险的增加相关。

原始出处:

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    2017-10-23 sjq027
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    2017-07-17 Jianghuiqin

    炎症性饮食是指什么呢?高糖高脂?

    0

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    2017-07-15 hfuym10906

    学习了学习了学习了学习了

    0

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    2017-07-14 半夏微凉

    慢性炎症可造成癌症。饮食通过改变炎症生物标志物的循环水平而在调节慢性炎症中起到重要作用。

    0

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2012年11月6日--最近,一个国际科学家小组研究发现了炎症性肠道疾病(IBD)的遗传基础。克罗恩氏病和溃疡性结肠炎是炎症性肠道疾病最常见的两种形式。 蒙特利尔心脏研究所与蒙特利尔大学医学副教授John Rioux博士已经确定了71个基因区域与炎性肠道疾病(IBD)发病有关,迄今发现与IBD发病相关的基因总数增加至163个。此外,该研究指出,这些基因区域表现出显著的重叠功效即也与自身免