JAMA Pediatr:极低体重儿和早产儿经母乳感染巨细胞病毒

2014-11-30 MedSci MedSci原创

极低体重儿(very low birth weight,VLBW)儿和早产儿生后容易感染巨细胞病毒(cytomegalovirus,CMV),和CMV相关脓毒症样综合征(CMV-related sepsis-like syndrome,CMV-SLS)。 亚特兰大州埃默里大学的Cassandra Josephson博士等人采取系统综述和meta分析的方法研究了VLBW儿经母乳感染CMV和CMV-

极低体重儿(very low birth weight,VLBW)儿和早产儿生后容易感染巨细胞病毒(cytomegalovirus,CMV),和CMV相关脓毒症样综合征(CMV-related sepsis-like syndrome,CMV-SLS)。

亚特兰大州埃默里大学的Cassandra Josephson博士等人采取系统综述和meta分析的方法研究了VLBW儿经母乳感染CMV和CMV-SLS的混合比例,这些婴儿的母亲血清CMV均为阳性。这一研究结果发表在今年9月份的JAMA Pediatrics上。

研究者将混合比例与人群为基础的CMV血清阳性率、母乳喂养率、VLBW出生率以及早产儿出生率相比较,研究美国每年经母乳感染CMV和CMV-SLS婴儿的患病率。

在这项meta分析中,共纳入299名未经处理母乳喂养的婴儿,研究发现平均19%(11%–32%)的婴儿感染CMV,4%(2%–7%)患CMV-SLS。在这一比例的研究基础上,研究者估计VLBW儿和早产儿经母乳感染CMV和CMV-SLS的患病率分别为6.5%(3.7%–10.9%)和1.4%(0.7%–2.4%),该结果与2008年600名CMV-SLS婴儿的数值相一致。在212名冷冻母乳喂养的婴儿中,CMV感染率为13%(7%–24%),CMV-SLS感染率为5%(2%–12%),结果比经母乳感染CMV的感染率低(4.4%; 2.4%–8.2%),但两者的CMV-SLS感染率相似(1.7%; 0.7%–4.1%)。

研究表明,经母乳感染CMV和CMV-SLS具有相关性。目前,需要进一步对于疾病负担的研究,进而制定新的指南,指导CMV血清阳性的孕妇母乳喂养VLBW儿和早产儿。

原始出处

Josephson CD1, Caliendo AM2, Easley KA3, Knezevic A3, Shenvi N3, Hinkes MT4, Patel RM5, Hillyer CD6, Roback JD7.Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants : a prospective cohort study.JAMA Pediatr. 2014 Nov 1

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    2015-07-07 feather89
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    2014-12-01 villahu
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    2014-12-01 wwzzly

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