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Biofouling：松油烯-4-醇和香芹酚可显著减少口腔生物膜的细菌量

2019-07-28 不详 网络

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本研究旨在研究松油烯-4-醇（T4ol）和香芹酚对单种和多种生物膜的细胞毒活性和抑制作用。 在口腔角质形成细胞上测试每种化合物的毒性，并通过XTT测定评估。通过结晶紫测定分析单种生物膜的抑制和根除，并通过qPCR评估对多物种生物膜组成的影响。 结果显示，与氯己定相比，T4ol和香芹酚不影响上皮细胞活力，氯己定显示出高细胞毒性作用。使用T4ol和香芹酚处理可抑制和根除单一生物膜。对于多物种生物膜，尤

本研究旨在研究松油烯-4-醇（T4ol）和香芹酚对单种和多种生物膜的细胞毒活性和抑制作用。

在口腔角质形成细胞上测试每种化合物的毒性，并通过XTT测定评估。通过结晶紫测定分析单种生物膜的抑制和根除，并通过qPCR评估对多物种生物膜组成的影响。

结果显示，与氯己定相比，T4ol和香芹酚不影响上皮细胞活力，氯己定显示出高细胞毒性作用。使用T4ol和香芹酚处理可抑制和根除单一生物膜。对于多物种生物膜，尤其是对牙周病原体，观察到相同的抑制作用。

总之，该研究结果表明，特定浓度的T4ol和香芹酚对上皮细胞无毒性，减少了单种和多种生物膜中牙周病原体的数量。

原始出处：

Maquera Huacho PM, Rodriguez Herrero E, et al., Terpinen-4-ol and carvacrol affect multi-species biofilm composition. Biofouling. 2019 Jul 8:1-12. doi: 10.1080/08927014.2019.1630386.

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    2019-10-29 sunylz

    #Bio#

    0

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    2019-08-05 ms8543593053280928

    #香芹酚#

    0

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    2020-02-21 weiz

    #细菌量#

    0