Circulation:急性风湿热与风湿性心脏病的长期结果

2016-07-21 fsy 译 MedSci原创

近期,来自澳大利亚的研究人员调查了急性风湿热(ARF)和风湿性心脏病(RHD)人群的不良预后,以及合并症和人口因素对这些结果的影响。研究人员统计了澳大利亚北部地区居民的数据(RHD登记,医院,和死亡数据)。在1997年到2013年期间,572名居民被诊断为ARF,1248名居民被诊断为RHD(这些人群中94.9%为原著民),研究人员计算了该人群的ARF复发率,从ARF进展到RHD再到严重RHD的发

近期,来自澳大利亚的研究人员调查了急性风湿热(ARF)和风湿性心脏病(RHD)人群的不良预后,以及合并症和人口因素对这些结果的影响。

研究人员统计了澳大利亚北部地区居民的数据(RHD登记、医院和死亡数据)。在1997年到2013年期间,572名居民被诊断为ARF,1248名居民被诊断为RHD(这些人群中94.9%为原著民),研究人员计算了该人群的ARF复发率,从ARF进展到RHD再到严重RHD的发病率,RHD并发症的发生率(心脏衰竭、心内膜炎、卒中和房颤)和死亡率。

在ARF发病后第一年中,ARF复发率最高(发生率,每100人-年3.7例),但低水平风险持续时间>10年。在第一年中,进展到RHD的发生率也是最高的(发生率,35.9),比ARF复发率高出近10倍。原著民被诊断为RHD时,年龄都较小,特别是男性(17岁)。RHD诊断后的第一年中并发症的发病率也是最高的:心衰发病率为每100人-年9.09例,房颤为4.70,心内膜炎为1.00;,卒中为0.58。原著民RHD患者比非原著民患者死亡率高(危险比,6.55;95%置信区间,2.45-17.51),其中28%可由肾功能衰竭合并症和使用有害酒精来解释。城市居民的RHD并发症和死亡率比偏远地区的居民要高。

本研究为ARF/RHD提供了新的重要的预后信息。在考虑合并症后,原著民RHD患者的生存差异依然持续存在,表明有其他因素会导致死亡,这值得进一步研究。

原始出处:

Vincent Y.F. He, John R. Condon, Anna P. Ralph,et al.Long-Term Outcomes From Acute Rheumatic Fever and Rheumatic Heart Disease,Circulation,2016.7.20

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

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