BMJ:孕妇甲状腺功能与儿童受教育程度有关?

2018-02-21 xing.T MedSci原创

由此可见,妊娠早期母体甲状腺功能异常与儿童学业不良或教育成就没有显著的临床联系。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在明确孕早期母体甲状腺功能紊乱是否是儿童学业成绩和总体教育程度的关键决定因素。

该研究为前瞻性队列研究,参与者为4615对孕早期(平均10周妊娠,间距范围8-12)血液标本可用的母子。研究人员连续测量了受试者游离甲状腺素、促甲状腺激素和甲状腺过氧化物酶抗体,并分为七个临床甲状腺功能类别。该研究的主要观察指标为在54个月时3580名进入评估阶段的儿童五个年龄特异性国家课程评估,以及至15岁最后的学校评估时增加到4461名儿童。

研究人员发现没有强有力的证据表明妊娠早期游离甲状腺素和促甲状腺激素水平与进入阶段评估评分或在任何关键阶段的标准评估测试评分有显著关联。孕妇游离甲状腺素或甲状腺刺激素水平与中等教育普通证书(GCSEs)通过(范围0-16)总数之间的相关性均接近于零:游离甲状腺素,每1pmol/L的比率为1.0(95%可信区间为1至1.01);促甲状腺激素,比率为0.98(0.94-1.02)。其中,200名(4.3%)母亲被确认为甲状腺功能减退症或亚临床甲状腺功能减退症,97名(2.1%)母亲被确诊为亚临床甲状腺功能亢进症或甲状腺功能亢进症。具有甲状腺功能障碍的母亲的孩子获得GCSE的数目和教育档次与母亲正常的儿童相同。

由此可见,妊娠早期母体甲状腺功能异常与儿童学业不良或教育成就没有显著的临床联系。

原始出处:

Scott M Nelson, et al. Maternal thyroid function and child educational attainment: prospective cohort study. BMJ 2018; https://doi.org/10.1136/bmj.k452.

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    2018-09-05 gaoxiaoe
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    2018-02-23 惠映实验室

    学习.谢谢分享.

    0

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    2018-02-21 wqkm

    ^_^^_^

    0

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