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Biomed Mater Eng：TCP-BG/PLLA复合支架或可用作骨再生支架材料

2018-01-19 MedSci MedSci原创

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本研究旨在分析30wt.%TCP-BG相对PLLA基复合支架在生物介质中降解和析出行为的共存效应。首先采用相分离法合成纯PLLA和三维复合支架，然后将其浸泡在SBF溶液中45 d。随后，通过分析浸入样品的pH值和重量变化，生物产物形成的能力和PLLA基质的相对分子量随着降解时间的变化来分析降解和沉淀特性。最后，使用Han和Pan模型对相对分子量变化的实验数据进行验证，并进行比较。结果表明复合支架表

本研究旨在分析30wt.%TCP-BG相对PLLA基复合支架在生物介质中降解和析出行为的共存效应。

首先采用相分离法合成纯PLLA和三维复合支架，然后将其浸泡在SBF溶液中45 d。随后，通过分析浸入样品的pH值和重量变化，生物产物形成的能力和PLLA基质的相对分子量随着降解时间的变化来分析降解和沉淀特性。最后，使用Han和Pan模型对相对分子量变化的实验数据进行验证，并进行比较。

结果表明复合支架表面沉积了大量的碳酸磷灰石，并且SBF介质的酸度变化适中，与纯PLLA支架相比，具有更好的生物活性。

综上所述，该研究结果表明，TCP-BG/PLLA复合支架具有很大的应用于骨替代或修复的潜力。

原始出处：

Ghasemi A, Hashemi B. Co-existence effect of tricalcium phosphate and bioactive glass on biological and biodegradation characteristic of Poly L-Lactic Acid (PLLA) in trinary composite scaffold form. Biomed Mater Eng. 2017;28(6):655-669. doi: 10.3233/BME-171707.

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    2018-08-22 tidiq

    #支架材料#

    0

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    2018-04-22 zhouqu_8

    #Eng#

    0

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    2018-06-06 sunylz

    #Bio#

    0

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    2018-01-30 1e16d8a5m40(暂无匿称)

    真心的不错

    0

  5. 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    2018-01-21 lsj630

    #骨再生#

    0

  6. 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    2018-01-21 ms3994565386320060

    #Med#

    0

  7. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jan 19 21:06:06 CST 2018, time=2018-01-19, status=1, ipAttribution=)]
    2018-01-19 李东泽

    是很好的学习材料.不错.以后会多学习.

    0

  8. 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    2018-01-19 有备才能无患

    本研究旨在分析30wt.%TCP-BG相对PLLA基复合支架在生物介质中降解和析出行为的共存效应.

    0

  9. 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    2018-01-19 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0