Invest Ophthalmol Vis Sci:青光眼患者的黄斑色素和视觉功能研究

2018-09-12 MedSci MedSci原创

美国汉密尔顿青光眼中心、Shiley眼科研究所和加利福尼亚大学圣地亚哥分校眼科的Daga FB、Ogata NG和Medeiros FA等人在Invest Ophthalmol Vis Sci发表了一项重要的研究。作者认为,虽然最近的研究表明黄斑色素(MP)在青光眼患者中显着降低,但这种关系值得进一步研究。

美国汉密尔顿青光眼中心、Shiley眼科研究所和加利福尼亚大学圣地亚哥分校眼科的Daga FB、Ogata NG和Medeiros FA等人在Invest Ophthalmol Vis Sci发表了一项重要的研究。作者认为,虽然最近的研究表明黄斑色素(MP)在青光眼患者中显着降低,但这种关系值得进一步研究。

他们采用横断面研究,包括85名青光眼患者和22名对照组的健康人。所有受试者均进行标准自动视野检查(SAP)和视网膜神经纤维层(RNFL)厚度测量。使用新型饮食筛选器估计叶黄素(L)和玉米黄质(Z)的摄入量。采用海德堡Spectralis双波长自发荧光(AF)技术研究MP和青光眼之间的关系。MP容量和青光眼之间的关联使用线性回归模型进行拟合,并在该模型中考虑潜在的混杂因素。

结果发现,与对照受试者相比,青光眼患者的SAP平均偏差(MD)和RNFL厚度更差(两者均P <0.001)。在单变量模型中,青光眼的诊断与MP容量无关(R2 = 1.22%; P = 0.257)。在单变量(P = 0.022)和多变量(P = 0.020)模型中,L和Z的膳食摄入与MP呈正相关,且具有显着的相关性。

因此,他们认为,这些结果挑战了之前的研究报告,即青光眼与低MP有关。在这个样本中,发现饮食习惯是MP的主要预测因子。同时,作者指出需要进一步的研究,以便更好地理解这些患者中青光眼、MP和视觉表现之间的关系。

原文出处:

Daga, F.B., et al., Macular Pigment and Visual Function in Patients With Glaucoma: The San Diego Macular Pigment Study. Invest Ophthalmol Vis Sci, 2018. 59(11): p. 4471-4476.

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    2019-02-09 sunylz
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    2018-09-14 zywlvao
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    2018-09-14 muzishouyi
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