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Int J Nanomed：FAgHA/TNT涂层可增强植体的抗菌成骨性能

2018-05-18 MedSci MedSci原创

FAgHA/TNT骨整合抗菌
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由于较差的机械性能，快速溶解率和缺乏抗菌活性限制了羟基磷灰石（HA）作为植体涂层材料的应用。为了克服这些限制，研究人员制备了Ag+取代的氟羟磷灰石和二氧化钛纳米管（TNT）的混合涂层。 将银掺入HA-TiO2杂化涂层改善了其抗菌活性。F作为第二种二元元素的添加增加了涂层的结构稳定性。使用X射线衍射、扫描电子显微镜、能量色散X射线光谱（EDS）和X射线光电子能谱（ XPS）证实Ti基底上TNT/F-

由于较差的机械性能，快速溶解率和缺乏抗菌活性限制了羟基磷灰石（HA）作为植体涂层材料的应用。为了克服这些限制，研究人员制备了Ag+取代的氟羟磷灰石和二氧化钛纳米管（TNT）的混合涂层。

将银掺入HA-TiO2杂化涂层改善了其抗菌活性。F作为第二种二元元素的添加增加了涂层的结构稳定性。使用X射线衍射、扫描电子显微镜、能量色散X射线光谱（EDS）和X射线光电子能谱（ XPS）证实Ti基底上TNT/F-和Ag-取代的HA（FAgHA）。

结果表明，FAgHA/TNT纳米复合涂层具有致密均匀的形态，具有纳米棒状结构。溶解度测量结果表明，将F-离子置换成AgHA结构对HA的耐溶解性具有积极作用。由于粗糙表面与进入TiO2纳米管空隙的纳米棒状颗粒互锁，FAgHA/TNT的粘合强度明显增加。与未涂覆涂层的Ti相比，FAgHA / TNT涂覆的Ti基体的腐蚀电流密度从3.71降低到0.18μA，且其耐腐蚀性增加了近两个数量级。而且，尽管有纯HA，但FAgHA在孵育24小时后杀死了所有的金黄色葡萄球菌。


虽然制造的FAgHA/TNT涂层是疏水性的，但当浸入模拟体液（SBF）时，它诱发了典型球形磷灰石的沉积，成骨细胞在涂层表面上铺展得非常好。另外，体外细胞培养试验表明细胞活力和碱性磷酸酶（ALP）与纯HA相似，这表明FAgHA/TNT具有良好的细胞相容性。更好的是，与裸Ti相比，FAgHA/TNT包被的Ti表面对细胞活力无影响，且更有利于体外细胞成骨。

综上所述，该研究结果表明，FAgHA/TNT涂层钛可增强骨结合并防止植入物感染，提高种植成功率。

原始出处：

Huang Y, Song G, et al., Nanostructured Ag+-substituted fluorhydroxyapatite-TiO2 coatings for enhanced bactericidal effects and osteoinductivity of Ti for biomedical applications. Int J Nanomedicine. 2018 May 3;13:2665-2684. doi: 10.2147/IJN.S162558. eCollection 2018.

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    2018-05-20 ms7899726347904398

    #抗菌#

    0

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    2018-05-20 zhaojie88

    #成骨#

    0

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    2018-05-20 ms3994565386320060

    #Med#

    0

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    2018-05-18 131****2916

    不错的文章值得推荐

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