BMJ:首例人际H7N9禽流感病毒传染病例

2013-08-07 koo bio360

8月7日,在研究禽流感新菌株的江苏省疾控中心科学家表示,很可能发生了首例人与人之间的所谓 H7N9 病毒的传染。 这一发现星期二发表在英国医学杂志BMJ上,重点介绍的是一名成年妇女和她 60 岁的父亲的病例。这名父亲三月份在去过活禽市场后染病,尽管接受了治疗并最后又住院,但还是在六星期后不治身亡。 研究人员表示,大多数病人看来都在去过活禽市场、或者与活禽有过密切接触的7到10天后开始发病。自从

8月7日,在研究禽流感新菌株的江苏省疾控中心科学家表示,很可能发生了首例人与人之间的所谓 H7N9 病毒的传染。

这一发现星期二发表在英国医学杂志BMJ上,重点介绍的是一名成年妇女和她 60 岁的父亲的病例。这名父亲三月份在去过活禽市场后染病,尽管接受了治疗并最后又住院,但还是在六星期后不治身亡。【原文下载

研究人员表示,大多数病人看来都在去过活禽市场、或者与活禽有过密切接触的7到10天后开始发病。自从三月份禽流感发生以来,已经有100多人感染,其中43人死亡。

在上述的父女病例中,那位先前健康的32岁妇女没有直接接触过活禽,但是她一直在生病父亲的床边直接照料护理,并且未曾采取防护措施,大约在她与父亲最后一次接触的一星期后,她也病倒了。她在一个月后死亡。

研究人员强调,尽管发生了这两起死亡病例,但是这两起病例却表明,这种病毒的自我传播能力显然还是“有限而且不能持续的”。

医务调查人员访问了43名跟这对父女有过密切接触的人,并让所有这些人作了禽流感病毒测试,全部结果都是阴性反应。

一些中国科学家4月份说,他们担心H7N9病毒在某些情况下在人与人之间传播。但是世卫组织稍后说,还没有确凿证据证实这种情况。

James W Rudge, Richard Coker. Human to human transmission of H7N9. BMJ 6 August 2013; doi: 10.1136/bmj.f4730

【原文下载】Xian Qi, Yan-Hua Qian, Chang-Jun Bao, Xi-Ling Guo, Lun-Biao Cui, Fen-Yang Tang, Hong Ji, Yong Huang, Pei-Quan Cai, Bing Lu, Ke Xu, Chao Shi, Feng-Cai Zhu, Ming-Hao Zhou, Hua Wang. Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ 6 August 2013; .doi: 10.1136/bmj.f4752

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    2013-10-20 gaoxiaoe
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大量生物特征表明,H7N9禽流感病毒对人类已构成重大威胁。最近,中国疾病预防控制中心病毒病预防控制所国家流感中心主任舒跃龙所带领的团队对H7N9的生物学特点进行了系统研究,相关研究成果发表在7月4日出版的《自然》杂志上。 “这些研究成果进一步说明H7N9病毒对人类健康可能产生的威胁,以及对该病毒进一步开展研究,加强对病毒流行和变异的监测是十分必要的。”舒跃龙在接受《中国科学报》记者采访时表示。

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2013年2月H7N9禽流感病毒在中国大陆人群中出现,到7月的第一个星期,世界卫生组织已记录到133个病例,其中包括43个死亡病例。迄今为止大部分病例都被发现与活禽市场有关。在本期Nature上,两个小组报告了H7N9的受体结合性质。这两个小组都发现,该病毒已获得了结合人“2,3-linked唾液酸受体”的能力,但却保留了与禽“2,3-linked受体”相结合的偏好,后者是一个可能限制其朝向在人类